Serine and cysteine proteases play a central role in digestion, protein degradation and in bioregulation. Their activity may be controlled by activation from inactive proenzyme forms and by inhibition by natural inhibitors. Detailed structural studies have provided a basis for understanding the ...
Serine and cysteine proteases in sul- fur mustard-exposed hairless mouse skin: Enzymatic activity and inhibition profiles. J. Toxicol. Cutan. Ocul. Toxicol. 19, 137-151.Casillas RP, Kam CM, Powers JC. Serine and cysteine proteases in sulfur mustard- exposed hairless mouse skin: enzymatic ...
1.Inhibits also some other serine and cysteine proteases like bromelain, ficin and papain. 1.也抑制其他的丝氨酸和半胱氨酸蛋白,如菠萝蛋白、果蛋白和木蛋白。 2.Snake venom thrombin-like enzymes belong to the fibrinogenolytic enzyme family and are serine proteases. 2.蛇毒类属于纤维蛋白原裂解,是一...
A novel class of peptide 伪-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M 1 --AA--NH--CHR 2 --CO--CO--NR 3 R 4 , M 1...
45 、Tripeptide aldehyde. Reversible competitive inhibitor ofserineand cysteine proteases. Inhibits also phospholipase D and C activation in rat hepatocytes.───三肽醛。丝氨酸和半胱氨酸蛋白酶可逆的竞争性抑制剂。也抑制鼠肝细胞中**酸酯酶D和C的活化。
Targeting Cysteine and Serine Proteases to Discover New Drugs Against Neglected Tropical Diseases doi:10.2174/092986733116240214143511Current Medicinal ChemistryIgor José dos Santos NascimentoRicardo Olimpio de Moura
assays using non-specific protein substrates on purified fecal and body extracts determined that body-associated activity is almost exclusively dependent on cysteine proteases, and specifically on major allergen Der p 1. By contrast, cysteine and serine proteases contributed similarly to the activity esti...
Results:Collagenaseandserineproteinaseactivitiesindiscsfrom model subgroups wereobviouslyhigherthanthoseofcontrolsubgroups. 结果:造模组动物颈椎间盘中胶原酶和丝氨酸蛋白酶活性明显高于各自的对照组。 dictsearch.appspot.com 5. Tripeptide aldehyde.Reversiblecompetitiveinhibitorofserineandcysteineproteases. ...
Since lysosomes contain a variety of proteases including both cysteine and serine proteases we were interested in the effects of inhibitors of these classes of enzymes on the intracellular growth and replication of Toxoplasma tachyzoites. It was hoped that the use of these inhibitors might provide ...
Changes in the P1 and P2 residues of these aldehydes, however, indicated that the amino acids occupying these positions are important for the efficient inhibition of γ-secretases. Peptidyl aldehydes inhibit both cysteine and serine proteases, suggesting that the two γ...