serine proteasesone-step processab initio studyH 2O moleculeThis work proposes a very detailed ab initio study of the hypothesis for a one-step serine protease acylation process with one water molecule acting as the main catalyst reactant. For the 11 increasing complexity models considered, the ...
The folding of the extracellular serine protease, α-lytic protease (αLP; EC 3.4.21.12) reveals a novel mechanism for stability that appears to lead to a longer functional lifetime for the protease. For αLP, stability is based not on thermodynamics, but on kinetics. Whereas this has requir...
High-temperature requirement protease A4 (HtrA4) is a secretary serine protease whose expression is up-regulated in pre-eclampsia (PE) and hence is a possible biomarker of PE. It has also been altered in cancers such as glioblastoma, breast carcinoma, and prostate cancer making it an emerging...
the NocTE very slowly hydrolyzedN-acetylcysteamine (SNAC) peptides containing a serine or alanine in position four regardless of the stereochemistry in the
Structure and Function of C1-Inhibitor Heterozygous deficiency of Cl-inhibitor (C1-INH) leads to the clinical picture of hereditary angioedema (HAE). C1-INH is a serine protease inhibitor (serpi... IGA Wagenaar-Bos,CE Hack - 《Immunology & Allergy Clinics of North America》 被引量: 126发表...
Glucuronoyl esterases (GEs) are α/β serine hydrolases and a relatively new addition in the toolbox to reduce the recalcitrance of lignocellulose, the biggest obstacle in cost-effective utilization of this important renewable resource. While biochemical and structural characterization of GEs have prog...
Using myeloperoxidase and hydrogen peroxide, activated neutrophils produce high local concentrations of hypochlorous acid (HOCl). They also secrete cathepsin G, a serine protease implicated in cytokine release, receptor activation, and degradation of tissue proteins. Isolated cathepsin G was inactivated by...
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serine protease; serum deprivation; tissue-type plasminogen activator Abstract Although the mechanism of action of tissue-type plasminogen activator (tPA) in excitotoxic necrosis is well documented, whether this serine protease can influence the apoptotic cascade remains a subject of debate. Here, we ...
Novel, selective mechanism-based inhibitors of herpes protease. Bioorg Med Chem Lett 1996;6:2467±2472.Pinto I.L., West A., Debouckm C.M., DiLella A.G., Gorniak J.G., O'Donnell K.C., O'Shannessy D.J., Patel A., and Jarvest R.L., Novel, selective mechanism-based ...