Today, however, catalysis by naturally occurring RNAs is rare and most chemical transformations within cells require proteins. This has led to interest in the design of small peptides capable of catalyzin...
Serine is formed fromthe glycolytic intermediate 3-phosphoglycerate in a three-step pathway beginning with the conversion of 3-phosphorylglycerate hydroxyl group to a ketone yielding 3-phosphohydroxypyruvate. Transamination of 3-phosphohydroxypyruvate forms phosphoserine that, upon hydrolysis, yields serine....
A family of serine proteases that are found primarily in the cytoplasmic granules of cytotoxic T lymphocytes and natural killer cells. They enter target cells through perforin pores, and cleave and activate intracellular caspases, resulting in target-cell apoptosis. Perforin A component of cytolytic gr...
Explain the mechanism of serine protease catalysis. Can you predict mechanisms of another class of proteases? Why is transfer RNA important to the production of proteins? Why is uracil used in RNA? Why can RNA bind to DNA? (a) Explain the k...
Nowadays, massive genomics and transcriptomics data can be generated at the single-cell level. However, proteomics in this setting is still a big challenge. Despite the great improvements in sensitivity and performance of mass spectrometry instruments and the better knowledge on sample preparation ...
摘要原文 Two completely flexible random chains containing N atoms joined by links of length L can be superimposed by rigid-body motions to match their structures as closely as possible. The statistics of the root-mean-square best-fit distance D are discussed. For long chains, D2 tends of 0.1...
Aberrant activation of the coagulation cascade of serine proteases may be contributory, perhaps through antibodies that cross-react with serine proteases and factor Xa.29 Other possible contributory factors include enhanced tissue factor expression and impaired activation of protein C.33 The multiple ...
By now we know that digestive enzymes are important for the breakdown and absorption of nutrients, but what are they exactly and how do they perform their vital functions? Learn more.
These molecules inhibit the priming of S protein by transmembrane protease serine 2 (TMPRSS2), an essential step for the fusion of viral and host cell membranes. In this context, nanomaterials can provide a unique characteristic of multivalent binding to the virus receptors. These nAbs or ...
amb1004d Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Caulobacter crescentus CB15 (AE005803-4) 1e − 17 MSR-1(ORF25, mamO)h e − 141 amb0969 e − 155 MS-1 (ZP_00053529.2) e − 162 MC-1 (ZP_00288338.1) 7e − 30 amb1005d Uncharacterized...