Cysteine proteinases of the papain superfamily are widely distributed in nature; they can be found in both prokaryotes and eukaryotes, e.g. bacteria, parasites, plants, invertebrates and vertebrates. In mammals, the major cysteine proteinases are the lysosomal cathepsins B and L. They are ...
On the other hand, the cysteine proteinases from C. candamarcensis described in this review, act as healers of chemically induced gastric ulcers and as antitumorals. Both, cathepsins and cysteine proteinases from Caricaceae belong to the same family of proteases (papain superfamily), which facts ...
cysteine proteinases [12,84,113–118]. However, growing experimental evidence suggests that additional mechanisms which are not related to itsproteinaseinhibiting functions might, in part, account for the antitumor effects of this protein [4,13,14,24,74] (Table 2,Fig. 1B). Although the ...
The cystatins: protein inhibitors of cysteine proteinases. The last decade has witnessed enormous progress of protein inhibitors of cysteine proteinases concerning their structures, functions and evolutionary relat... V Turk,W Bode - 《Febs Letters》 被引量: 1858发表: 1991年 The cystatins: Protein...
Compounds are provided that are useful in inhibiting cysteine or serine proteinases. The compounds define a peptide backbone with a sulfur atom substituted... MM Mader,PA Bartlett 被引量: 0发表: 1994年 An overview of the serpin superfamily Serine Proteinase InhibitorsProtein ConformationMutationSerpin...
Arthropod members of the cystatin superfamily belong to the stefin and cystatin lineages. Stefins were not present in the insect species and one stefin encoding gene was found in the genomes of the miteT. urticaeand in the crustaceanD. pulex. Architectures for proteins containing domains of the...
Coimbra, Joao Carlos; Pinto, Iraja Damiani; Wurdig, Norma Luiza; Do Carmo, Dermeval Aparecido 1992: Characterization by rapid-kinetic and equilibrium methods of the interaction between N -terminally truncated forms of chicken cystatin and the cysteine proteinases papain and actinidin Biochemical Journal...
The cysteine proteinases of Schistosoma mansoni cercariae Based on substrate preferences, cercariae of Schistosoma mansoni were seen to express both cathepsin L and cathepsin B cysteine proteinases, although the f... JP Dalton,KA Clough,MK Jones,... - 《Parasitology》 被引量: 92发表: 1997年 Mole...
Proteases, known as proteinases, peptide hydrolases, or peptidases otherwise, are hydrolase enzymes, primarily associated with catalyzing the hydrolysis of peptide bonds by the cleavage of amide linkages in a macromolecular or oligomeric protein. Essentially present in every organism, proteases play critica...
class II associated p-41 invariant chain and chum salmon egg cysteine proteinase inhibitor (ECI) were described as inhibitors of cysteine proteinases Therefore we suggest that equistatin belongs to a new superfamily of protein inhibitors of cysteine proteinases named thyroglobulin tvpe-1 domain ...