CYP3A4PharmacogeneticsPediatricDrug MetabolismCytochrome P450 3A4 (CYP3A4) is a crucial enzyme involved in the Phase I metabolism of numerous medications used in clinical practice. Its potential significance in pediatric pharmacotherapy is underscored by the unique metabolic profile of children, which ...
11 Moreover, it processes some of the cardiovascular medications such as antihypertensive medications (felodipine,76 amlodipine,77 nifedipine,78 statins79) and lipid-lowering medications (atorvastatin and simvastatin). CYP3A4 is also responsible for the clearance of some immune suppressant drugs such as...
Cytochrome P450 3A(CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in ...
Cytochrome P450 3A(CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in ...
Cytochrome P450 3A(CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in ...
Consultation with a psychiatrist or pharmacist is recommended before co-administering MAOIs and other antidepressant medications. 2. Consultation with a psychiatrist is recommended before prescribing antidepressants to pregnant females. 3. CAUTIONARY NOTE REGARDING USE OF ANTIDEPRESSANTS IN PATIENTS WITH ...
释义: 全部 1. KnockingCYP3A4outofactionmeanshigherbloodlevelsofthesemedications. 使CYP3A4失效意味着这些药物更高的血液水平。 news.dxy.cn 2. Scientistssaidtheysuspectedthatanenzymeingrapefruitknownas CYP 3A4hadtheabilitytoincreaseestrogen. 科学家们说,他们怀疑在葡萄柚中有一种叫做CYP3A4的酶,能够增加雌...
南方医科大学2011级硕士学位论文构建适于药物研发的CYP3A4高表达细胞模型的研究ConstructingaCeUModelwithEnhancedExp..
Thus, patients with severe coeliac disease would probably experience similarly altered drug response, including overdose toxicity, from many important medications known to be metabolised by CYP3A4. Patients with coeliac disease with severe disease should be considered for other clinical drug management, ...
While recruiting participants, we ensured that all their concurrent medications would not interact with atorvastatin treatment or affect the analysis or the study objectives. In the same context, none of the study subjects had used lipid-lowering agents for at least one month before this research. ...