11 Moreover, it processes some of the cardiovascular medications such as antihypertensive medications (felodipine,76 amlodipine,77 nifedipine,78 statins79) and lipid-lowering medications (atorvastatin and simvastatin). CYP3A4 is also responsible for the clearance of some immune suppressant drugs such as...
释义: 全部 1. KnockingCYP3A4outofactionmeanshigherbloodlevelsofthesemedications. 使CYP3A4失效意味着这些药物更高的血液水平。 news.dxy.cn 2. Scientistssaidtheysuspectedthatanenzymeingrapefruitknownas CYP 3A4hadtheabilitytoincreaseestrogen. 科学家们说,他们怀疑在葡萄柚中有一种叫做CYP3A4的酶,能够增加雌...
Yes, it's well-known that grapefruit juice can interact with many medications, including certain cholesterol-lowering statin drugs, blood pressure drugs, antihistamines, and sedatives. One of the ways grapefruit does this is by inhibiting CYP3A4, an enzyme in the liver and intestine that helps...
While recruiting participants, we ensured that all their concurrent medications would not interact with atorvastatin treatment or affect the analysis or the study objectives. In the same context, none of the study subjects had used lipid-lowering agents for at least one month before this research. ...
Cytochrome P450 3A(CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in ...
CYP3A4,5,7底物 抑制剂 诱导剂
Introduction: In the last 20 years of clinical practice, the senior author has identified these 2 rare cases who needed extremely high doses of CYP3A4 medications to reach and maintain serum therapeutic concentrations. Methods: The high metabolic ability of these two patients was demonstrated by ...
Drugs that inhibit CYP3A4 activity will almost always increase the plasma concentrations of the CYP3A4 substrate medications. Some drugs, such as clarithromycin, itraconazole, and ketoconazole, are particularly potent inhibitors of CYP3A4; patients on these drugs may have markedly reduced CYP3A4 acti...
Cytochrome P450 3A(CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in ...
<MissingAbstract>The cytochrome P450 3A4 enzyme (CYP3A4) is one of the most abundant human P450s. CYP3A4 catalyses the oxidative metabolism of a wide array of different chemicals with markedly different structural characteristics, including testosterone and many commonly used medications (Bertz & ...