A single nucleotide polymorphism (SNP) is a variation in the DNA sequence that results from the alteration of a single nucleotide in the genome. Atorvastatin is used to treat hypercholesterolemia. It belongs to a class of drugs called statins, which lower elevated levels of total cholesterol (TC...
Although CYP3A4 is predominantly found in the liver, it is also present in other organs and tissues of the body where it may play an important role in metabolism. CYP3A4 in the intestine plays an important role in the metabolism of certain drugs. Often this allows prodrugs to be activated...
cytochrome P450 enzymes, such as CYP1A2, EYP2D6, CYP2C9, and CYP2CI9, play a minor role in its metabolism. The main circulating active metabolite in humans is the N-demethylated piperazine derivative, formed predominantly by CYP3A4. It shows in vi CYP3A4是主要enxyme负责任对imatinib新...
But the difference between the Japanese and the US population is substantial at all ages. It is not known whether the current increase in the mortality ... JAH Lee - 《International Journal of Epidemiology》 被引量: 45发表: 1976年 Poison Woman: Figuring Female Transgression in Modern Japanese...
Purpose The objective of this work was to determine the incidence and clinical importance of this drug interaction (DI), how to manage it and what are the non-interacting alternatives. Material and methods A review was conducted of the scientific literature, drug databases and regulatory documents...
According to these models, the highest fraction of drug absorbed occurred in the slow (60%) [37] and the medium kinetic absorption phases (61%, MTT = 4.82 h) [35], which probably represent what occurs at the more distal parts of the small intestine as described before for LCP_Tac [46...
In more detail, we investigated the following: (i) whether CYP3A4 overexpression influences the rate and pattern of drug metab- olism, (ii) whether the drug modulates CYP3A4 activity in a cellular system and (iii) what the impact of CYP3A4 overex- pression on cell cycle progression and...
An of the article "Absorption of Quinidine Is Influenced By Intestinal P-Glycoprotein and CYP3A4 in Humans," by Hartmut Glaeser and Siegfried Drescher is presented. Using a multiluminal perfusion catheter, the absorption of intraluminally administered Q was investigated in 8 male health volunteers ...
Therefore, it may not be appropriate for de novo transplant recipients receiving LCP-Tac. Another limitation is the low prevalence of PM patients in the Caucasian population. Further studies with a larger sample size are required to improve the model and confirm the current results regarding the ...