明确CYP3A4、MDR1和SLCO1B1基因相关位点多态性与高脂血症患者阿伐他汀血药浓度和调脂疗效的相关性,并对这些基因的变异位点进行联合分析,从而筛选出与阿伐他汀治疗相关的遗传标志物,为实现以基因为导向的药物治疗和个体化给药提供实验依据。
The CYP3A4*1B (T/T) and CYP3A5*3 (C/C) genotypes significantly improved the serum triglyceride (TG) level (P < 0.05) and elevated the TB level (P < 0.001). Atorvastatin plasma levels were greater in CYP3A4*1B (T/T) (P < 0.05) and CYP3A5*3 (C/C) (P <...
respectively. TheCYP3A4*1B(T/T) andCYP3A5*3(C/C) genotypes significantly improved the serum triglyceride (TG) level (P < 0.05) and elevated the TB level (P < 0.001). Atorvastatin plasma levels were greater inCYP3A4*1B(T/T) (P < 0.05) andCYP3A5*3(C/C) (P <...
CYP3A4*1 Reference Standard询价 产品描述 产品数据库 CBPA0115 Format Genomic DNA Description CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with CYP3A4 include Vitamin D-Dependent Rickets, Type 3 and Acetaminophen Metabolism. ...
病情描述:cyp3a4指的是什么 医生回答方承康 主任医师 三甲 南昌大学第一附属医院 中医科Cyp3a4全称为P4503A4细胞色素酶,是人体内一种重要的酶,主要存在于肝脏和小肠内,它能对毒素、药物等外源有机小分子进行氧化,从而将它们排出体外。Cyp3a4酶可以使很多药物失去活性,但是同时它还可以提高某些药物的活性,例...
Regarding adverse effects, significant associations were found between CYP3A4*1B and PXR 69789GG variants and impaired liver function (p = 0.040 and p = 0.049, respectively). Considering both variants, 66.66% of the cases were carriers of the CYP3A4*1/*1B-PXR 69789GG combination, all of...
CYP3A4抑制剂是什么意思 CYP3A4抑制剂通常指的是能够降低CYP3A4酶活性的药物或化合物。CYP3A4是一种广泛存在于肝脏和肠道中的酶,参与了许多药物的代谢过程。 CYP3A4抑制剂通过与CYP3A4酶结合,减少其代谢能力,从而影响其他药物的代谢速率。这可能导致某些药物在体内的浓度升高,增加不良反应的风险。例如,某些抗生素...
We found that the G allele and GG genotype of CYP3A4*1B polymorphism were associated with increased risk of cancers using the fixed effects model (allele model: odds ratio (OR) = 1.24, 95 %CI: 1.09–1.42, P = 0.001; recessive model: OR = 1.77, 95 %CI: 1.30–2.41, ...
CYP450 3A4 (CYP3A4), encoded by the =0.001; recessive model: OR=1.77, 95 %CI: 1.30–2.41, =0.004). Subgroup analyses by cancer type showed that the G allele and G carrier (AG+GG) of CYP3A4*1B poly...
Single nucleotide polymorphisms were examined in the cytochrome 450 3A4 ( CYP3A4 ) and N -acetyltransferase 2 ( NAT2 ) genes, which code for major mediators of the metabolism of a wide variety of therapeutic drugs, as well as xenobiotics. We determined,