CYP3A4*1 Reference Standard询价 产品描述 产品数据库 CBPA0115 Format Genomic DNA Description CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with CYP3A4 include Vitamin D-Dependent Rickets, Type 3 and Acetaminophen Metabolism. ...
respectively. TheCYP3A4*1B(T/T) andCYP3A5*3(C/C) genotypes significantly improved the serum triglyceride (TG) level (P < 0.05) and elevated the TB level (P < 0.001). Atorvastatin plasma levels were greater inCYP3A4*1B(T/T) (P < 0.05) andCYP3A5*3(C/C) (P <...
The CYP3A4*1B (T/T) and CYP3A5*3 (C/C) genotypes significantly improved the serum triglyceride (TG) level (P < 0.05) and elevated the TB level (P < 0.001). Atorvastatin plasma levels were greater in CYP3A4*1B (T/T) (P < 0.05) and CYP3A5*3 (C/C) (P <...
CYP450 3A4 (CYP3A4), encoded by the =0.001; recessive model: OR=1.77, 95 %CI: 1.30–2.41, =0.004). Subgroup analyses by cancer type showed that the G allele and G carrier (AG+GG) of CYP3A4*1B poly...
The results indicated that there was no signicant association between CYP3A4*1B gene polymorphism and bladder cancer risk (OR=1.83, 95% CI=0.97-3.46, P=0.062). Also no association was found with individuals carrying the *3 genotype of CYP3A5 gene with bladder cancer in this study among ...
Single nucleotide polymorphisms were examined in the cytochrome 450 3A4 ( CYP3A4 ) and N -acetyltransferase 2 ( NAT2 ) genes, which code for major mediators of the metabolism of a wide variety of therapeutic drugs, as well as xenobiotics. We determined,
一种检测CYP3A4*1G和MDR1C1236T的基因多态性的HRM方法专利信息由爱企查专利频道提供,一种检测CYP3A4*1G和MDR1C1236T的基因多态性的HRM方法说明:本发明属于分子生物学和医学领域,公开了一种检测CYP3A4*1G和MDR1C1236T的基因多...专利查询请上爱企查
Differences in expression and activity of cytochrome P450 (CYP) 3A4 and 3A5 affect these pharmacokinetics; cytochrome activity differences are associated with CYP genetic polymorphisms.Material/Methods:This study evaluated the effects of polymorphisms in CYP3A4 and CYP3A5 on immunosuppressive drug-dose ...
When Co/dose were compared, CYP3A4*1B allele carriers had four-fold fewer values compared to non-carriers. Regarding adverse effects, significant associations were found between CYP3A4*1B and PXR 69789GG variants and impaired liver function (p = 0.040 and p = 0.049, respectively). ...
CYP3A4抑制剂通常指的是能够降低细胞色素P4503A4酶活性的药物或化合物。这种酶在肝脏中广泛存在,参与许多内源性和外源性物质的代谢过程。 CYP3A4抑制剂的作用机制主要有两种,一是与CYP3A4酶的活性位点结合,阻止底物与酶的结合;二是改变CYP3A4酶的构象,降低其催化活性。这类药物在临床上的应用十分广泛,如抗真菌...