Described herein is a computer program product for pharmacy management and its application for using drugs that are P-glycoprotein or CYP3A4 inhibitors. Also included is a method of using a first drug in a patient receiving a prescription for the first drug. The computer program performs a ...
Medications that are substrates for CYP3A4/5 (such as contraceptives, cyclosporine, midazolam, and triazolam). These may not be as effective when taken in combination with modafinil Contraceptives in particular may not be as effective while taking modafinil and for one month after discontinuing it....
Doxazosin may interact with some drugs, including phosphodiesterase-5 (PDE-5) inhibitors (such as sildenafil and vardenafil), drugs that inhibit CYP 3A4 hepatic enzymes, and those that also lower blood pressure or cause dizziness. Should not be taken by people who are allergic to doxazosin or ...
Therefore, mTOR inhibitors block cell-cycle progression from G1 to S phase [25]. The lack of an inhibition on the axis IL-2/IL-2 receptor might explain a beneficial effect on the T-reg population, that seem to be increased in mTORi treated patients. Importantly, these drugs are not ...
The chemicals involved in grapefruit juice, Seville oranges and pomelos are calledfuranocoumarins. These are metabolized by CYP3A4 to compounds that bind to and block the active site of the enzyme, causing irreversible inactivation. CYP3A4 activity in the small intestine is thus impaired until yo...
(eg, from 400 mg to 200 mg); if strong CYP3A4 inhibitors are used (eg, voriconazole or posaconazole), we recommend reducing the venetoclax daily dose by at least 75% (eg, from 400 mg to 100 mg); pharmacokinetic studies have shown that venetoclax 50 mg daily when coadministered with ...
This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I representAUTHOR OF THIS BLOG DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER ...
This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I representAUTHOR OF THIS BLOG DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER ...
Pharmacokinetic interaction possible with drugs that are inhibitors of CYP3A4. Vaginal Preparations Progesterone vaginal gel (Crinone): Do not administer concurrently with other vaginal preparations.If therapy with another agent administered intravaginally is needed, administer the other agent 6 hours before...
Concomitant Use with Hydroxymethylglutaryl CoA (HMG-CoA) Reductase Inhibitors (Statins)Concomitant use with certain statins that are metabolized by CYP3A4 (e.g., simvastatin, lovastatin) may result in increased exposure to the statin and possible increased risk of myopathy, including rhabdomyolysis. ...