CYP3A4 inhibitors, such as grapefruit, can interact with certain medications by inhibiting the liver enzyme that metabolizes many drugs. ConsumerLab.com's answer explains.
Zopiclone (Imovane) CYP3A4 Inhibitors Drugs that inhibit CYP3A4 activity will almost always increase the plasma concentrations of the CYP3A4 substrate medications. Some drugs, such as clarithromycin, itraconazole, and ketoconazole, are particularly potent inhibitors of CYP3A4; patients on these drugs ...
(proton pump inhibitors, statin/fibrate use, calcium channel blockers), and CYP2C19 metabolizer status. Impaired renal function was defined as serum creatinine level ≥ 200 µmol/L. The CYP2C19 metabolizer status was categorized into three groups: normal metabolizer (*1/*1 genotype), intermediate...