CYP3A4 inhibitors, such as grapefruit, can interact with certain medications by inhibiting the liver enzyme that metabolizes many drugs. ConsumerLab.com's answer explains.
A small percentage of children are prescribed medications that could inhibit or induce CYP3A4 activity, with 3% of patients exposed to CYP3A4 inhibitors and less than 1% to CYP3A4 inducers. Common inhibitors included medications such as fluoxetine and ranitidine. Given the metabolism of opioids li...
Tyrosine kinase inhibitors (TKIs) serve as targeted anticancer drugs that inhibit the abnormal activity of tyrosine kinase (TK) in cancer treatment. However, when used with other medications, they often result in side effects, such as renal impairment, hepatic injury, and even mortality. This ...
CYP3A4 inhibitors also share distinctive structural fea- tures that enable them to interact with and block the enzyme's activity. Many inhibitors contain nitrogen atoms (e.g., imidazoles, triazoles, or pyridines), which coordinate with CYP3A4's heme iron, effectively inhibiting access to the ...