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摘要: CYP3A家族(cytochrome P450,subfamilyⅢA)是细胞色素酶CYP450(cytochrome P450 enzyme system)重要成员,其含量丰富,底物覆盖广泛,主要功能是参与许多内,外源性物质的代谢,是药物代谢反应中最主要的限速酶.关键词:CYP3A4 CYP3A5 多态性 肿瘤 P450 代谢反应 细胞色素酶 外源性物质 ...
西北大学硕士学位论文人CYP3A4两个新非同义突变酵母表达系统的建立及其多态性在体外代谢和药物筛选中研究姓名:***请学位级别:硕士专业:微生物学指导教师:**20100601摘要人细胞色素P450(CYP)超家族是一类混合功能单加氧酶,主要存在于肝微粒体中,参与内源性化合物(如胆汁酸、甾体类激素、脂肪酸、前列腺素等)和外源...
cyp3a4的表达和活性在不同个体间存在高达几十倍的差异,而这种巨大的差异在临床上经常引起严重的药物相互作用和不良反应(zangerumandschwabm.cytochromep450enzymesindrugmetabolism:regulationofgeneexpression,enzymeactivities,andimpactofgeneticvariation.pharmacolther.2013;138(1):103-141.)。cyp3a4的表达差异受遗传因素...
1. KnockingCYP3A4outofactionmeanshigherbloodlevelsofthesemedications. 使CYP3A4失效意味着这些药物更高的血液水平。 news.dxy.cn 2. Scientistssaidtheysuspectedthatanenzymeingrapefruitknownas CYP 3A4hadtheabilitytoincreaseestrogen. 科学家们说,他们怀疑在葡萄柚中有一种叫做CYP3A4的酶,能够增加雌激素。
Cytochrome P-450 Enzyme SystemCholesterolHeptanoic AcidsTriglyceridesLipoproteinsGenotypeCholesterol, HDLCholesterol, LDLTo test whether genetic variation in the CYP system may influence the statin response, a promoter (A-290G) and 2 nonsynonymous polymorphisms (F189S and M445T) in the CYP3A4 gene ...
China isacommondiseaseinnervous aremetabolized 【Abstract】Epilepsy system.Mostantiepilepticdrugs by liver as P450 iSthemost inP450 enzymes.suchcytochromeenzyme.CYP3A4importantenzyme family. involvedinthemetabolismofabout40%一60%ofthe useforclinic.Italsohasaclose with drugs relationship themetabolismof ...
themRNAexpressioninducedbysingledruggroupisinconsistentwiththechangeoftheenzymeactivity,suggestingthatthedrugmaydirectlyactontheenzymeactivitylink.TraditionalChinesemedicine(TCM)isacomplexsystem,andmanykindsofcompoundsinteractwitheachother,sothatthemetabolismofasingledrugorasinglecomponentcannotrepresentthemetabolisminacompound...
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展开 关键词: Cytochrome P 450 Enzyme System Microsomes, Liver Mixed Function Oxygenases Vinblastine Vinca Alkaloids Chromatography, High Pressure Liquid Dose Response Relationship, Drug Enzyme Inhibitors Hydroxylation Isoenzymes 被引量: 92 年份: 2000 收藏...