Objective: The aim of this study was to quantify how often CYP2D6 substrates were dispensed in patients receiving mirabegron among adults of any age and among those ≥ 65 years of age. Methods: In this retrospective descriptive analysis, a deidentified administrative claims database...
The effects of its marked genetic polymorphism on the individual capacity to metabolize drugs are well known, but its role in metabolism of neural substrates affecting behavior personality or cognition, suggested by its CNS expression, is a long-standing unresolved issue. To verify earlier findings ...
探针底物代谢产物/CYP450 probe substrates/metabolites: 对乙酰氨基酚(CYP1A2) 7-羟基香豆素(CYP2A6) 羟基安非他酮(CYP2B6) 6-羟基紫杉醇(CYP2C8) 4-羟基甲苯磺丁脲(CYP2C9) 右啡烷/去甲基右美沙芬(CYP2D6) 5-羟基奥美拉唑(CYP2C19) 4-羟基美芬妥因(CYP2C19) 6-羟基氯唑沙宗(CYP2E1) 1-羟基咪达坐...
Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. CYP2D6 is located in the endoplasmic reticulum where it oxidizes substrates such as drugs and environmental chemicals. CYP2D6 metabolizes more than 25% of current commonly used drugs including antidepressants, ...
美芬妥因(CYP2C19) 右美沙芬(CYP2D6) 氯唑沙宗(CYP2E1) 咪达坐仑 midazolam(CYP3A4) 睾酮(CYP3A4) 探针底物代谢产物/CYP450 probe substrates/metabolites: 对乙酰氨基酚(CYP1A2) 7-羟基香豆素(CYP2A6) 羟基安非他酮(CYP2B6) 6-羟基紫杉醇(CYP2C8) ...
"Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.". Drug Metab. Rev. 36 (2): 243-77. PMID 15237854.v • d • eOxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) 1.14.11 - 2-oxoglutarate Prolyl hydroxylase - Lysyl hydroxylase 1.14.13 ...
CYP2D6 is located in the endoplasmic reticulum where it oxidizes substrates such as drugs and environmental chemicals (1,2). CYP2D6 metabolizes more than 25% of current commonly used drugs including antidepressants, antipsychotics, analgesics, beta-adrenergic blocking agents, antiarrythmics, and ...
characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ult...
Komura H,Iwaki M.Usefulness of hepatocytes for evaluating the genetic polymorphism of CYP2D6 substrates. Xenobiotica . 2005Komura H and Iwaki M (2005) Usefulness of hepatocytes for evaluating the genetic polymor- phism of CYP2D6 substrates. Xenobiotica 35:575-587....
探针底物代谢产物/CYP450 probe substrates/metabolites: 对乙酰氨基酚(CYP1A2) 7-羟基香豆素(CYP2A6) 羟基安非他酮(CYP2B6) 6-羟基紫杉醇(CYP2C8) 4-羟基甲苯磺丁脲(CYP2C9) 右啡烷/去甲基右美沙芬(CYP2D6) 5-羟基奥美拉唑(CYP2C19) 4-羟基美芬妥因(CYP2C19) ...