Gene CYP2D6*2 Mutation Type 1 AA Change: p.R296C DNA Change: NM_000106.6:c.886C>T Chr position (GRCh38): NC_000022.11:g.42127941G>A Mutation Type 2 AA Change: p.S486T DNA Change: NM_000106.6:c.1457G>C Chr position (GRCh38):NC_000022.11:g.42126611C>G Allelic Freque...
CYP2D6*2_p.R296C Reference Standard询价 产品描述 产品数据库 CBPA0003 Format Genomic DNA Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been ...
与CYP2D6相关的药物有125种，40种具有1A级别的证据等级，意味着在使用药物前应进行基因检测。CYP2D6酶在所有参与药物代谢的细胞色素P450酶中唯一非诱导酶，导致遗传变异对酶活性的个体差异影响显著。CYP2D6基因高度多态性，超过100个已知等位基因分为功能正常（*1和*2）、功能减弱（*9、*10和*41）及无...
CYP2D6 2*突变株 + 还原酶 , 产品编号 品名 规格 CYP/EZ027 CYP2D6 2*突变株 + 还原酶 0.5nmol P450 at 1nmol/ml, 10mg/ml protein 此产品为汇智泰康自主研发生产,产品品牌GTox。此类产品主要用
人们已经发现CYP2C19有超过30个等位基因变异体。大部分病人携带的是CYP2C19*1,*2,或*17等位基因,其中CYP2C19*1编码正常功能酶,CYP2C19*2是最常见的无功能基因,其次是CYP2C19*3。CYP2C19*17等位基因是启动子区域的一种变体,该变体导致基因转录增强,从而增加了代谢能力[2]。
2. CYP2D6在药物代谢中的作用 2.1 药物代谢的机制 CYP2D6酶在药物代谢中起着关键作用,其代谢活性与药物在体内的浓度及疗效密切相关。研究显示,CYP2D6的酶活性与多种精神药物的血浆浓度呈负相关关系。例如,在抑郁症治疗中,CYP2D6的活性降低会增加患者出现副作用的风险,而酶活性过高则可能导致药物反应不佳。
对高频基因突变位点进行基因检测的局限性包括局限性包括:(1)可能无法检测到由佳学基因检测进行检测与分析变异;(2)未测试的已知星号()等位基因将不会报告,而是将该等位基因报告为1;(3)测试不设计检测未知或新发现的变异体。 如何区分他莫昔芬药物敏感性基因解码、基因检测?
Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated with risks of various cancers (PMID: 22994728, PMID: 16550168) and may alter the ...
Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated with risks of various cancers (PMID: 22994728, PMID: 16550168) and may alter the ...
CYP2D6*2_p.S486T Reference Standard 详细介绍 CBPA0001 Format Genomic DNA Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated with ris...