CYP2D6*2_p.S486T Reference Standard询价 产品描述 产品数据库 CBPA0001 Format Genomic DNA Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been ...
CYP2C9基因多态性用药指导标准品 联系我们 联系人:蒋经理 电话:4008750250 号码: 手机:18066071954 地址:南京市栖霞区纬地路9号 Email: zhangxiangwen@cobioer.com 产品展示/PRODUCTS 基因检测标准品>用药指导> CBPA0045CYP2D6*2 Reference Standard 名称CYP2D6*2 Reference Standard ...
CYP2D6*2_p.S486T Reference Standard 详细介绍 CBPA0001 Format Genomic DNA Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated with ris...
PROBLEM TO BE SOLVED: To provide a method for detecting the mutation (C2850T mutation) at the 2850 site of the cDNA of CYP2D6 gene.;SOLUTION: The mutation is detected by using a nucleic acid probe having a specific base sequence, produced by amplifying a region containing a C2850T mutati...
Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated with risks of various cancers (PMID: 22994728, PMID: 16550168) and may alter the ...
CYP2D6*2 Polymorphism as a Predictor of Failed Outpatient Tramadol Therapy in Postherpetic Neuralgia Patients. Nasare NV,Banerjee BD,Suryakantrao Deshmukh P,etal.CYP2D6*2 Polymorphism as a Predictor of FailedOutpatient Tramadol Therapy in Postherpetic NeuralgiaPatients... NV Nasare,BD Banerjee,PS ...
The allele frequencies ofCYP2D6*1,CYP2D6*2,CYP2D6*4,CYP2D6*10,CYP3A5*1, andCYP3A5*3were 72.9%, 3.2%, 1.1%, 22.8%, 37.3%, and 62.7%, respectively, while the genotype frequencies ofCYP2D6*1/*1,CYP2D6*1/*2,CYP2D6*2/*2,CYP2D6*4/*4,CYP2D6*1/*10,CYP2D6*2/*10,CYP2D6*4/*...
人们已经发现CYP2C19有超过30个等位基因变异体。大部分病人携带的是CYP2C19*1,*2,或*17等位基因,其中CYP2C19*1编码正常功能酶,CYP2C19*2是最常见的无功能基因,其次是CYP2C19*3。CYP2C19*17等位基因是启动子区域的一种变体,该变体导致基因转录增强,从而增加了代谢能力[2]。
与CYP2D6相关的药物有125种，40种具有1A级别的证据等级，意味着在使用药物前应进行基因检测。CYP2D6酶在所有参与药物代谢的细胞色素P450酶中唯一非诱导酶，导致遗传变异对酶活性的个体差异影响显著。CYP2D6基因高度多态性，超过100个已知等位基因分为功能正常（*1和*2）、功能减弱（*9、*10和*41）及无...
对高频基因突变位点进行基因检测的局限性包括局限性包括:(1)可能无法检测到罕见的变异;(2)未测试的已知星号()等位基因将不会报告,而是将该等位基因报告为1;(3)测试不设计检测未知或新发现的变异体。 如何区分他莫昔芬药物敏感性基因解码、基因检测? 基因解码在检测的基因信息量、分析解读的方式方法上要明显优于...