Opioids are widely used in the treatment of moderate to severe pain.However,there are wide inter-individual variabilities in analgesic efficacy and adverse reactions.Pharmacogenetics study shows that gene polymorphism was closely related to the above interindividual variabilities,and more research was focuse...
Recently, Zackrisson et al, in "High Frequency of Occurrence of CYP2D6 Gene Duplication/ Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases," reported an association between CYP2D6 ultrarapid metabolizer (CYP2D6 UM) genotypes and suicide completion. We wondered whether CYP2D6 gene ...
该液相芯片可用于检测CYP2D6基因的两种正常基因型CYP2D6*1和CYP2D6*2以及五种国内常见突变基因型CYP2D6*3、CYP2D6*4、CYP2D6*5、CYP2D6*10和CYP2D6的基因重复(Gene Duplication)突变。 一种CYP2D6基因突变检测液相芯片,包括有: (A).针对CYP2D6 C2850T、CYP2D6 Deletion的突变位点的ASPE引物:每种ASPE引物由3’...
1995. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population. Clin Pharmacol Ther 57: 265-269.Agu´ndez,J.A., Ledesma,M.C., Ladero,J.M. and Benitez,J. (1995) Prevalence of CYP2D6 gene duplication and its repercussion on the ...
"Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians". Pharmacogenetics 7 (3): 187–91. PMID 9241658. ^ a b Droll K, Bruce-Mensah K, Otton SV, Gaedigk A, Sellers EM, Tyndale RF (1998). "Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and...
Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. Keulen, JT, Bauer, S, Roots, I, Brockmoller, J (2008) Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol... J Kirchheiner,JTHA Keulen,S Bauer,... - ...
Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes 1 The nomenclature for CYP2D6 alleles follows the new system described by Daly et al. (1996) . Therefore, designations of the CYP2D6 alleles discussed ...
CYP2D6不同变体或不同等位基因功能性定义 GENE:CYP2D6 NucleotidechangesNG_008376.3startingat ATG 14C>T 19G>A 31G>A 64delC Effectonprotein(NP_000097.3)A5V V7M V11M L22X PositionatNC_000022.11(Homosapienschromosome 22,GRCh38.p2)g.42130778G>A g.42130773C>T g.42130761C>T g.42130728del...
et al. CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res 12, R64 (2010). https://doi.org/10.1186/bcr2629 Download citation Received04 March 2010 Revised08 July...
由于 CYP2D6存在假基因, [3] ZaekrissonAL,LindblomB,AhlnerJ.Highfrequencyof CYP2D7和CYP2D8以及CYP2D6和CYP2D7的融合使 occurrenceofCYP2D6geneduplieation/muhiduplicationin— 研究变得很复杂,在实验设计及分析解释时需要引 dicatinguhrarapidmetabolismamongsuicidecases[J]. 起注意 。这些传统方法可重复性差...