We evaluated the effect of single nucleotide polymorphisms (SNPs) representing known functional variants (PM, IM and UM; minor allele frequency (MAF) > 0.01) on clinical outcome after adjuvant tamoxifen therapy. We also carried out an empirical evaluation of common genetic variation in CYP2D6 and...
Its activity ranges from complete deficiency to excessive activity, potentially causing toxicity of medication or therapeutic failure with recommended drug dosages. This study aimed to describe the CYP2D6 diversity at the global level. METHODS: A total of 1060 individuals belonging to 52 worldwide-...
Genetic VariationNumerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40-60%). Our study is the ...
Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-dependent drugs on risperidone metabolism in patients with schizophrenia. The CYP2D6*10 polymorphism and the presence of co-medication exerted significant influences on the pharmacokinetics of risperidone. Copyright 2009 John Wi... T Yagi...
Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40-60%). Our study is the largest investigat...
Genetic variation in POR could also contribute to variability in observed cytochrome P450 oxidoreductase (CYP2D6) activ- ity.30 Furthermore, inhibition of CYP2D6 enzymatic activity by concomitant medication(s) can dramatically change a person's metabolic capacity presenting with a phenotype that does ...
The efficacy of a drug therapy is influenced by many different factors such as age, weight, comorbidity and co-medication, which vary between patients, as well as fixed parameters such as gender and pharmacogenetic characteristics. Many enzymes involved in drug metabolism are genetically polymorphic,...
to provide the basis for individualized clinical medication,this paper interprets the guidelines,including summarizing CYP2D6,OPRM1,and COMT gene polymorphism of opioid analgesic effect and adverse reactions and putting forward treatment suggestions based on CYP2D6 genotype to guide clinical use codeine,...
chain reaction, quantitative multiplex polymerase chain reaction, high-resolution melting analysis, and/or Sanger sequencing.CYP2D6genotyping by Stargazer was 99.0% concordant with the data obtained by these methods, and showed that 28.1% of the samples had structural variation includingCYP2D6/CYP2D7...
Comprehensive CYP2D6 genotype, adherence and co-medication affect outcome in breast cancer patients treated with tamoxifen monotherapy The association between CYP2D6 genotype and outcome in breast cancer patients treated with adjuvant tamoxifen remains controversial. We assessed the influe... Alastair M. ...