按基因型可分为:在外显子1第188位点上携带两个有活性等位基因的野生型纯合子C/C(CYP2D6*1/*1),携带两个导致酶活性降低的等位基因的突变纯合子T/T(CYP2D6*10/*10)和只含一个正常等位基因的杂合子C/T(CYP2D6*1/*10)。诸多研究表明西方人与东方人间CYP2D6*10等位基因突变频率存在明显种族差异,而我国...
别与等位基因C 188 →T的2种存在形式结合并延伸。根据扩增出条带的长度来确定等位基因类型。为 了提高方法的特异性,在内引物的3′端一定位置引入了一个人工错配碱基 [6,7] ,以降低非特异性带的生 成及避免假阳性结果的出现。此外,还在两条内引物5′端附加一段由10个G和C组成且与模板DNA ...
人CYP2D6*10基因100C>T点突变探针法qPCR检测试剂盒(不含内参)50T 5900元英文名称:Human CYP2D6*10 Gene100C>T Point Mutation Probe Realtime PCR Detection Kit (without internal control)运输:Cold保存:-20℃有效期:1 Year货期:1 Month其他:产品介绍:收起...
960化工网为您提供CYP2D6*10、CYP2C9*3、ADRB1(1165G>C)、AGTR1(1166A>C)、ACE(I/D)和MTHFR(677C>T)基因检测试剂盒(荧光PCR-毛细管电泳法)的专业供应商信息,包括公司名称,地址,手机,电话,以及该供应商的其他产品和相关产品。17721545752 (微信同号) 商务合作对接 4000 025 960 全国400免费热线 专业网站...
Substitutions (188T and 4268C) were introduced into the pcDNA3.1-CYP2D6*1 vector using the QuikChange Site-directed Mutagenesis Kit (Stratagene, Shang- hai, China). The mutation primers are listed in Supplementary Table 1. The constructs were sequenced to confirm the intro- duction of these ...
CYP2D6*10 heterozygous mutated alleles (C/T) were also a common genotype that presented in 22 (26.2%) of the study subjects. Variant *17 was less common and was detected only as heterozygous (C/T) in 3 patients (3.6%). No CYP2D6*3 heterozygous or homozygous mutated alleles were ...