参考答案:细胞色素P450 2D6 (CYP2D6)是细胞色素P450 (CYP)超家族成员之一。这个巨大的酶超家族参与药物和其他外源性物质的生物转化,以及内源性化合物(如类固醇激素)的代谢。CYP2D6参与几种常用药物的生物转化,包括抗精神病药、抗抑郁药、止痛药、β -阻滞剂和抗心律失常药。在CYP亚型中,CYP2D6基因被认为是多态性...
Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population. To study the frequency of CYP2D6(*)10 and (*)14 alleles in a healthy Chinese population, and the influence of these two alleles on the metabolic activity o......
In this study, we evaluate, for the first time, the influence of CYP2D6, CYP2C9 and ABCB1 genotypes on the steady-state plasma concentrations of fluoxetine and its active metabolite (S)-norfluoxetine, and on the clinical improvement in children and adolescent patients receiving fluoxetine ...
目的:探讨细胞色素 P4502D6(CYP2D6)基因多态性对接受他莫昔芬(TAM)治疗 ER 阳性乳腺癌患者预后的影响。方法采用 PCR 法检测2010年3月~2011年3月106例接受 TAM治疗的 ER 阳性乳腺癌患者外周血 CYP2D6基因型,分别采用χ2检验...
是他莫西分需要做CP6的检测吗?不一定。 嗯,指南没有推荐一定要做,如果基因提示都是野生型,它意味着代谢快吗? 呃,它其实是怕那个慢代谢型,因为他莫西芬在体内的话呢,它是需要转换成吲哚西分才起效的,那CYPRD6的话呢,它就是起到这样子的一个转换的效应,如果CYP
The purpose of this study was to explore the association of CYP2D6 genotypes with pain and PONV in orthopedic trauma patients admitted for surgical repair of a single isolated fracture. Methods: Subjects (n=143) aged 18-70 were recruited for this exploratory descriptive study. Subjects were ...
摘要: 目的 探讨首发抑郁症患者CYP2D6基因位点rs1065852多态性、炎症因子和单胺类神经递质变化临床意义.方法 选取首发抑郁症患者97例(抑郁症组)和健康体检者78名(对照组),采用RT-PCR检测CYP2D6基因位点rs1065852多态性基因频率和基因型分布;采用酶联免疫吸附法测定白介素-1β(IL-1β)、白介... 查看全部>> ...
Anti-CYP2D6 Polyclonal Antibody-Cy3.5 产品说明书 试用装申请 Cat:K109188P-Cy3.5 Solarbio 宿主:Rabbit 交叉反应:Rat ; Human 稀释比例:WB 1:1000-3000. 别名:Cytochrome P450 2D6;CYPIID6;Cholesterol 25-hydroxylase;Cytochrome P450-DB1;Debrisoquine 4-hydroxylase;CYP2DL1 储存条件:Store at -20℃. ...
The CYP2D gene cluster on human chromosome 22 containing the functional cytochrome P450 gene CYP2D6 and two or three highly homologous pseudogenes is involved in a clinically important variation in the inactivation of drugs and environmental chemicals. Several mutant haplotypes of CYP2D6 have been iden...