目的:评价试验制剂氯沙坦钾片(杭州民生药业)与参比制剂氯沙坦钾片(杭州默沙东制药)的生物等效性及CYP2C9*3基因多态性对氯沙坦药代动力学的影响。方法:采用PCR测序法对健康中国汉族受试者CYP2C9*3(rs1057910A>C)位点进行基因分型,筛选36名受试者入组本试验,其中CYP2C9*1/*1(AA)基因型个体32例,CYP2C9...
10q24 Cytochrome P450 family 2, subfamily C, polypeptide 9 CYP2C9 *3, 1075A>C rs1057910
This study was designed to evaluate the effect of the warfarin dose-associated genotypes, CYP2C9*3 (rs1057910), VKORC1 -1639 G/A (rs9923231), and CYP4F2 13... M Cong,Y Zhang,X Qiang,... - 《International Journal of Hematology》 被引量: 39发表: 2012年 Clinical Practice Recommendat...
CYP2C9*2和CYP2C9*3是CYP2C9基因的突变型,它们分别由rs1799853和rs1057910位点的单核苷酸多态性引起 2楼2023-12-12 16:36 回复 开饭了_吗- 初级粉丝 1 其中,CYP2C9*2是由rs1799853位点的C>T突变引起的,这种突变导致CYP2C9酶活性下降,从而影响对某些药物的代谢能力3...
This study was designed to evaluate the effect of the warfarin dose-associated genotypes, CYP2C9*3 (rs1057910), VKORC1 -1639 G/A (rs9923231), and CYP4F2 13... M Cong,Y Zhang,X Qiang,... - 《International Journal of Hematology》 被引量: 39发表: 2012年 Responsiveness to low-dose...
多元线性回归建立给药模型,探讨基因多态性对华法林维持剂量的影响.结果 VKORC1-3673G>A,CYP2C9*3,CYP4F2 rs2108622基因多态性和患者年龄,体质量能解释45.2%的华法林维持剂量差异.CYP2C19*2基因多态性对本研究人群华法林维持剂量无影响.结论 VKORC1-3673G>A,CYP2C9*3,CYP4F2 rs2108622基因多态性显著影响...
The reference DNA sequence of the target variant CYP2C9*3 was retrieved (rs1057910), and the genomic DNA was amplified using the selected forward primer from chromosome passion at 94981018 to 94981037 bp (GTGCATCTGTAACCATCCTC) and the reverse complementary primer from chromosome passion at 949...