UnivRasmaizatulUnivAkmaUnivAnnals of Human Biology: Journal of the Society for the Study of Human BiologyRosdi, R.A.; Mohd Yusoff, N.; Ismail, R.; Soo Choon, T.; Saleem, M.; Musa, N.; Yusoff, S. High allele frequency of CYP2C9*3 (rs1057910) in a Negrito's subtribe ...
10q24 Cytochrome P450 family 2, subfamily C, polypeptide 9 CYP2C9 *3, 1075A>C rs1057910
目的:评价试验制剂氯沙坦钾片(杭州民生药业)与参比制剂氯沙坦钾片(杭州默沙东制药)的生物等效性及CYP2C9*3基因多态性对氯沙坦药代动力学的影响。方法:采用PCR测序法对健康中国汉族受试者CYP2C9*3(rs1057910A>C)位点进行基因分型,筛选36名受试者入组本试验,其中CYP2C9*1/*1(AA)基因型个体32例,CYP2C9...
图1为采用试剂盒中的检测基因rs1057910位点的两个上游引物以及两个下游引物检测样品得到凝胶电泳图,其中m为dna的marker,1、3、5位上游引物的电泳图,2/4/6位下游引物电泳图; 图2为采用试剂盒中的检测基因rs9923231位点的两个上游引物以及两下游引物检测样品得到凝胶电泳图,其中m为dna的marker,2、4、6位上游引物...
适用范围/预期用途本试剂盒用于体外定性检测人全血样本基因组DNA中CYP2C9*3(rs1057910,1075A>C)、VKORC1(rs9923231,-1639G>A)两个位点多态性。 型号规格24人份/盒 产品储存条件及有效期本试剂盒应储存于-18℃以下的避光条件下,有效期12个月。
方法:采用 PCR 测序法对健康中国汉族受试者CYP2C9*3(rs1057910A>C )位点进行基因分型,筛选36名受试者入组本试验,其中CYP2C9*1/*1(AA )基因型个体32例, CYP2C9*1/*3(AC )基因型个体4例。本研究为两制剂、两周期交叉设计,单次、开放口服给药的 单中心试验,给药剂量为氯沙坦钾片(50mg/片)1片...
所述阳性对照包含:CYP2C9 rs1057910位点野生型质粒、CYP2C9 rs1057910位点突变型质粒、CYP2D6 rs1065852位点野生型质粒、CYP2D6 rs1065852位点突变型质粒、ADRB1rs1801253位点野生型质粒、ADRB1 rs1801253位点突变型质粒、AGTR1 rs5186位点野生型质粒、AGTR1 rs5186位点突变型质粒、ACE rs4646994位点野生型质粒、...
Results Diversity of CYP2C9*3 in Indian Populations The A>C (rs1057910/CYP2C9*3) is a non-synonymous mutation, which replace isoleucine with leucine (ATT>CTT; Ile359Leu) and decreases enzyme activity. To explore the "C" allele frequency in Indian populations, initially we confirmed Hardy...
CYP2C9is responsible for S-warfarin (the more active enantiomer) clearance. The 2 most common reduced-function variants are *2 (rs1799853) and *3 (rs1057910). TheCYP2C9*2 allele reduces warfarin clearance by 30% and the *3 allele by 90% (79), which translate into 19% and 33% re...
cypc2c9*2(rs1799853,c430t,arg144cys)和cyp2c9*3(rs1057910,a1075c,ile359leu)均导致cyp2c9酶活性降低,cyp2c9*3纯合子个体酶活性仅为该位点野生型纯合子基因型个体(携带cyp2c9*1或arg144/ile359等位基因)的4～6%。中国人群中cypc2c9*2的频率为0%,cypc2c9*3的频率为3%。cyp2c9*3纯合子华...