To the best of our knowledge, the effects of the CYP3A4*1B (rs2740574 C/T) or CYP3A5*3 (rs776746 T/C) polymorphisms on atorvastatin efficacy and safety in Egyptians have not been previously studied. Numerous studies have evaluated the impact of CYP3A4 and CYP3A5 genetic polymorphisms ...
also carried out on 100 prostate cancer patients and 100 controls, among Yoruba men in Nigeria, to investigate the allelic variants of CYP3A4*1B (rs2740574 A>G) using polymerase chain reaction restriction fragment length polymorphism... KH Tijani - 《Molecular & Cellular Biology》 被引量: 0...
The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to investigate the association between CYP3A4*1B (rs2740574 A > G) polymorphism and cancer risk. Eleven studies were included with a total of 3,810 cancer patients and 3,173 healthy controls. We found that...
Logistic regression as an extrapolation model revealed that both theCYP3A4*1B(rs2740574C/T) genotype (C/T) and (T/T) were predictors of theCYP3A5*3(rs776746T/C) genotype (T/C) and (C/C), respectively. Logistic regression revealed a significant relationship between theCYP3A5*3(T/C)...
Figure 2. Weight-adjusted dose for each genotypic group (rs2740574). Figure 3. Co/dose for each genotypic group (rs2740574). ** TAC Blood levels were obtained in a limited number of patients. Patients’ phenotypes were classified as fast metabolizers (CYP3A5-expressers and CYP3A4*1B...