T‐ARMS‐PCR(rs12248560) is a functional single nucleotide polymorphism (SNP) in the gene. It has been shown that is associated with the clinical outcome of some drugs metabolized by CYP2C19 and a decreased risk of some diseases. The aim of this study was to develop a reliable and simple ...
In the present study we analyzed the association of three polymorphisms of CYP2C19 namely CYP2C19*2 (CYP2C19-681-G>A, rs4244285), CYP2C19*3 (CYP2C19-636-G>A, rs57081121) and CYP2C19*17 (CYP2C19--806-C>T, rs12248560), with breast cancer susceptibility. We genotyped 1,015 breast cancer ...
CYP2C19*2 and *17 is de?ned by rs4244285 and rs12248560, respectively. Patients were classi?ed according to their genotypes as poor metabolizers (*2 “loss-of-function” allele carriers/*17 “gain-of-function” allele noncarriers), intermediate metabolizers (*2 “loss-of-function” allele ...
目的探讨潍坊地区汉族冠心病患者CYP2C19*2,CYP2C19*3,CYP2C19*17位点基因多态性分布特征,为抗血小板药物个体化治疗提供依据.方法选取2016年11月~2020年1月在我院就诊的冠心病患者240例,采用数字荧光分子杂交技术检测CYP2C19*2(rs4244285),CYP2C19*3(rs4986893)和CYP2C19*17(rs12248560)基因位点多态性.结果240例潍坊地区汉...
The results showed that the A allele of the TNF-伪 rs1800629 G>A SNP is linked to CAD with odd ratio (OR) (95% CI) = 2.10, p-value = 0.0013. The T allele of the CYP2C19*17 (rs12248560) C>T is linked to CAD with OR (95% CI) = 2.02, p-value = 0...
DNA was extracted from leukocytes and all patients and controls were genotyped for two SNPs (rs4244285 and rs12248560) of CYP2C19 gene by allele specific polymerase chain reaction (AS-PCR). Results: Multi-allelic polymorphism in CYP2C19 identified four distinct phenotypes known as ultra...