CYP2C19基因*2/*17(-806Tc,636GG)阳性的意思如下：CYP2C19酶的编号遗传基因为CYP2C19遗传基因，坐落于人类10号性染色体上。CYP2C19遗传基因带有42个等位基因，CYP2C19*1为野生型等位基因，其编号的酶具备一切正常特异性。CYP2C19*2（rs4244285，c.681G>A）和CYP2C19*3（rs4986893，c.636G>A）编号的CYP2...
In the present study we analyzed the association of three polymorphisms of CYP2C19 namely CYP2C19*2 (CYP2C19-681-G>A, rs4244285), CYP2C19*3 (CYP2C19-636-G>A, rs57081121) and CYP2C19*17 (CYP2C19--806-C>T, rs12248560), with breast cancer susceptibility. We genotyped 1,015 breast cancer ...
Methods We hypothesised that the eight closely-linked clinically important SNPs in the CYP2C family of genes, namely CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17 predispose to PUD via impaired NSAID metabolism as well ...
Objective: To investigate the relationship between rs2576178 mutation of renalase gene (RNLS) and the incidence of hypertension of type 2 diabetic nephropathy patients with micro-albuminuria. Methods: A total of 225 type 2 diabetic nephropathy patients with micro-albuminuria (DN group, all Han natio...
作者: RS Pedersen,C Brasch-Andersen,SC Sim,TK Bergmann,J Halling,MS Petersen,P Weihe,H Edvardsen,VN Kristensen,K Br?Sen 展开 摘要: Purpose To determine the distribution of clinically important CYP2C genotypes and allele frequencies in healthy Nordic populations with special focus on linkage ...
CYP2C19*2 and *17 is de?ned by rs4244285 and rs12248560, respectively. Patients were classi?ed according to their genotypes as poor metabolizers (*2 “loss-of-function” allele carriers/*17 “gain-of-function” allele noncarriers), intermediate metabolizers (*2 “loss-of-function” allele ...
目的探讨潍坊地区汉族冠心病患者CYP2C19*2,CYP2C19*3,CYP2C19*17位点基因多态性分布特征,为抗血小板药物个体化治疗提供依据.方法选取2016年11月~2020年1月在我院就诊的冠心病患者240例,采用数字荧光分子杂交技术检测CYP2C19*2(rs4244285),CYP2C19*3(rs4986893)和CYP2C19*17(rs12248560)基因位点多态性.结果240例潍坊地区汉...
Pedersen RS, Brasch-Andersen C, Sim SC, Bergmann TK, Halling J, Petersen MS, Weihe P, Edvardsen H, Kristensen VN, Brøsen K, Ingelman-Sundberg M (2010) Linkage disequilibrium between the CYP2C19*17 allele and wildtypeCYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in he...
(CYP2C19_681_G>A, rs4244285), CYP2C19*3 (CYP2C19_636_G>A, rs57081121) and CYP2C19*17 (CYP2C19_-806_C>T, rs12248560), with breast cancer susceptibility. We genotyped 1,015 breast cancer cases and 1,021 age-matched, population-based controls of the German GENICA study by matrix ...
[0009] 所述的CYP2C19(*2、*3、*17)基因多态性SNaPshot检测方法,所述检测位点 包括 67/^67讲2: c.681G>A(p.Pr〇227=)(SNP:rs4244285); 67/^67讲3: c.636G>A(p. Trp212Ter)(SNP:rs4986893); 67/^67讲17: c.-806C>T(SNP:rsl2248560)。[0010] 所述的CYP2C19(*2、*3、*17)基因多态性...