CYP2C19基因*2/*17(-806Tc,636GG)阳性的意思如下：CYP2C19酶的编号遗传基因为CYP2C19遗传基因，坐落于人类10号性染色体上。CYP2C19遗传基因带有42个等位基因，CYP2C19*1为野生型等位基因，其编号的酶具备一切正常特异性。CYP2C19*2（rs4244285，c.681G>A）和CYP2C19*3（rs4986893，c.636G>A）编号的CYP2...
In the present study we analyzed the association of three polymorphisms of CYP2C19 namely CYP2C19*2 (CYP2C19-681-G>A, rs4244285), CYP2C19*3 (CYP2C19-636-G>A, rs57081121) and CYP2C19*17 (CYP2C19--806-C>T, rs12248560), with breast cancer susceptibility. We genotyped 1,015 breast cancer ...
Methods We hypothesised that the eight closely-linked clinically important SNPs in the CYP2C family of genes, namely CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17 predispose to PUD via impaired NSAID metabolism as well ...
作者: RS Pedersen,C Brasch-Andersen,SC Sim,TK Bergmann,J Halling,MS Petersen,P Weihe,H Edvardsen,VN Kristensen,K Br?Sen 展开 摘要: Purpose To determine the distribution of clinically important CYP2C genotypes and allele frequencies in healthy Nordic populations with special focus on linkage ...
CYP2C19*17基因与氯吡格雷出血风险之间的关系 祁蕙,孙红,陈慧(福建省立医院药学部,福州350001)摘要:目的:探讨CYP2C19*17等位基因变异对国人冠心病患者PCI术后应用氯吡格雷出血事件是否有影 响。方法:研究2010年1月至2011年4月间福建省立医院心内科择期进行皮冠状动脉介 入术成功的冠心病患者520例,PCI术前常规服用阿司...
目的探讨潍坊地区汉族冠心病患者CYP2C19*2,CYP2C19*3,CYP2C19*17位点基因多态性分布特征,为抗血小板药物个体化治疗提供依据.方法选取2016年11月~2020年1月在我院就诊的冠心病患者240例,采用数字荧光分子杂交技术检测CYP2C19*2(rs4244285),CYP2C19*3(rs4986893)和CYP2C19*17(rs12248560)基因位点多态性.结果240例潍坊地区汉...
CYP2C19*2 and *17 is de?ned by rs4244285 and rs12248560, respectively. Patients were classi?ed according to their genotypes as poor metabolizers (*2 “loss-of-function” allele carriers/*17 “gain-of-function” allele noncarriers), intermediate metabolizers (*2 “loss-of-function” allele ...
[0009] 所述的CYP2C19(*2、*3、*17)基因多态性SNaPshot检测方法,所述检测位点 包括 67/^67讲2: c.681G>A(p.Pr〇227=)(SNP:rs4244285); 67/^67讲3: c.636G>A(p. Trp212Ter)(SNP:rs4986893); 67/^67讲17: c.-806C>T(SNP:rsl2248560)。[0010] 所述的CYP2C19(*2、*3、*17)基因多态性...
In this study, we examined the link between single nucleotide variations (SNVs) of TNF-伪-rs1800629 G>A, CYP2C19*17 (rs12248560) C>T, and miR-423 rs6505162 C>A and the expression of TNF-伪 with CAD. We used the mutation specific PCR, ARMS-PCR, and ELISA. ...
The Effect of CYP2C19*2 (rs4244285) and CYP17 (rs743572) SNPs on Adriamycin and Paclitaxel based Chemotherapy Outcomes in Breast Cancer Patientsdoi:10.31557/APJCP.2024.25.6.1977Gudur, Rashmi A.Bhosale, Suresh J.Gudur, Anand K.Kale, Shivani R....