Yang SH, Lee MG (2008) Effects of CYP inducers and inhibitors on the ondansetron pharmacokinetics in rats: involvement of CYP2D subfamily and 3A1/2 for the ondansetron metabolism. J Pharm Pharmacol 60:853–861YANG SH,LEE MG.Effects of cytochrome P450(CYP)inducers and inhibitors on ondansetron...
To investigate the metabolic enzymes of the two compounds and the drug-drug interactions with enzyme inducers or inhibitors, a series of in vitro and in vivo experiments were conducted. In vitro studies using recombinant human cytochrome P450 enzyme demonstrated that cytochrome P450 3A4 (CYP3A4) ...
Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMUEffects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of ...
[4] Rendic S, Ci Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997;29:413-580. [5] Ince I, Knibbe CA, Danhof M, et al. 2013. Developmental changes in the expression and function of cytochrome ...
[4] Rendic S, Ci Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997;29:413-580. [5] Ince I, Knibbe CA, Danhof M, et al. 2013. Developmental changes in t...
节选自FDA《Table of Substrates, Inhibitors and Inducers》 诱导/抑制剂也有强弱之分,包括但不限于: 节选自UpToDate-2022 * 根据 FDA系统分类为 CYP3A4 的弱抑制剂。 ¶根据 FDA系统分类为 CYP3A4 的弱诱导剂。 药物相互作用纷繁复杂,远非上表所能概括,建议读者用药前进...
Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver [ J] . Drug Metab Dispos, 1999, 27(2) : 188 - 192. [ 5 ] Edson KZ, Rettie AE. CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and ...
Metabolic pathwayEnzymeInductionThis chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.doi:10.1007/978-1-4614-7495-1_7Jennifer DeCouNathaniel BirgenheierRandal O. DullSpringer New York...
表 1 实验所用探针底物,抑制剂,诱导剂 Table 1 Probe substrates, inhibitors and inducers used in this study CYP 酶 体外探针底物 名称 浓度/(μmol·L−1) 体外阳性抑制剂 名称 浓度/(μmol·L−1) 体外阳性诱导剂 名称 浓度/(μmol·L−1) 体内探针底物 名称 给药量/(mg·kg−1) CYP1A2...
Effects of fish cytochromes P450 inducers and inhibitors on difloxacin N-demethylation in kidney of Chinese idle (Ctenopharyngodon idellus) inhibitioninductionkineticCytochromes P450 (CYPs) play key roles in drug metabolism which are widely distributed in kidney in aquatic organisms. CYP(s) ... ZY ...