Many of the major CYP450s are now well characterised and typical substrates, inhibitors or inducers documented, there is a comprehensive list of compounds interacting with CYP450s here. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (...
Name the CYP 450 inducers Definition 1A2 tobacco 2C9 rifampin (powerful inducer) 2E1 ethanol, isoniazid 34A - Carbamarazpine - and inhibitor and an inducer Term What is tobacco? Definition 1A2 Inducer Term Name a powerful inducer that is used as an agent to eliminate antibiotics Definition ...
CYP2D6 Inducers The evidence suggests that, unlike most other CYP450 enzymes, CYP2D6 is not very susceptible to enzyme induction. Thus, genetics, rather than drug therapy, accounts for most ultrarapid CYP2D6 metabolizers. Drugs Activated by CYP2D6 Codeine Codeine is largely a prodrug, and its ...
Substrates Inhibitors Inducers Often mentioned [2]: some Antidepressants Amitriptyline (tricyclic antidepressant) Imipramine (antidepressant) Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic) Caffeine (stimulant) Olanzapine (atypical antipsychotic) Ropivacaine (local anaesthetic) ...
In DDI clinical studies, it is customary to use inhibitors and inducers which are known to have a strong effect. In most cases, rifampicin is used as an inducer and ketoconazole or itraconazole as an inhibitor. However, the strength of effect of a perpetrator is dependent on the metabolic ch...
Human CYP2C8: Structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms. Curr. Drug Metab. 2009, 10, 1009–1047. [Google Scholar] [CrossRef] Li, X.Q.; Bjorkman, A.; Andersson, T.B.; Ridderstrom, M.; Masimirembwa, C.M. Amodiaquine clearance and its metabolism...