This review presents a comprehensive update on the inhibitors and inducers of the specific CYP enzymes in humans. The focus is on the more recent human in vitro and in vivo findings since the publication of our previous review on this topic in 2008. In addition to the general presentation of...
To investigate the metabolic enzymes of the two compounds and the drug-drug interactions with enzyme inducers or inhibitors, a series of in vitro and in vivo experiments were conducted. In vitro studies using recombinant human cytochrome P450 enzyme demonstrated that cytochrome P450 3A4 (CYP3A4) ...
CYP2E1PharmacokineticMetabolismMetabolic pathwayEnzymeInductionThis chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 2E1.doi:10.1007/978-1-4614-7495-1_6Benjamin S. GmelchUniversity of Utah School of MedicineRandal O. Dull...
CYP4 enzymes as potential drug targets: focus onenzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities [J]. Curr Top Med Chem, 2013, 13(12): 1429-1440. [6] Moya-Alvarado G, ...
CYP/Transporter- and Induction-Based Interactions and Multiple- Inhibitor Drug Interaction Studies: Relevant Principles of Drug Interaction Concept Paper Shiew-Mei Huang, Ph.D. Deputy Director for Science Office of Clinical Pharmacology & Biopharmaceutics ...
enzyme.MethOds The related literatures at home and abmad with clinical research or case report about clinicaI dmg interactions reIatedto s仃ong inhibitors and s仃ong inducers of CYP3A4 enz)rIIle were consulted and s眦lm撕zed.ReSuIts nlerc are m卸y clinicalreports about strong inhibitors of ...
medical orders of psychiatric inpatients from July 1 to December 31, 2018 in the First Hospital of Hebei Medical University was carried out, and ≥2 medical orders were used in combination to record the CYP450 enzyme substrates, inhibitors, or inducers were contained in the combined drug use. ...
Enzyme phenotyping for the formation of ART-M (10β–hydroxyartemisinin) from artemisinin (ART; 1 µM) using human liver microsomes (HLM, 1 mg/mL) in the presence of (non)selective inhibitors of total P450 enzymes (1-ABT), CYP1A2 (α-naphthoflavone, NAPH), CYP2B6 (ticlopidine, TCL)...
Metabolic pathwayEnzymeInductionThis chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 3A4.doi:10.1007/978-1-4614-7495-1_7Jennifer DeCouNathaniel BirgenheierRandal O. DullSpringer New York...
The elimination criteria were: incomplete sampling, serious adverse effects during treatment, and acute renal or hepatic dysfunction developed during the study. Concomitant medications were recorded during the hospital stay and classified as CYP3A4 substrates, inducers, or inhibitors. 2.2. Peripheral ...