The objective of this study was to extend this method to drug interactions caused by CYP1A2 inhibitors and inducers. Methods First, initial estimates of the model parameters were obtained using data from the literature. Then, an external validation of these initial estimates was performed by ...
CYP1A2: The switch-hitierThis chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 1A2doi:10.1007/978-1-4614-7495-1_8Danielle RousselEmily HagnRandal O. Dull
Substrates Inhibitors Inducers Often mentioned [2]: some Antidepressants Amitriptyline (tricyclic antidepressant) Imipramine (antidepressant) Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic) Caffeine (stimulant) Olanzapine (atypical antipsychotic) Ropivacaine (local anaesthetic) ...
charbroiled foods, andcruciferous vegetables. Several medications induce CYP1A2 activity, includingphenytoin,phenobarbital, andrifampin.Omeprazoleandritonavirsimultaneously may induce CYP1A2 and inhibit one or more other CYPisoenzymes. Inhibitors of CYP1A2 includeerythromycin,ciprofloxacin,fluvoxamine, and grape...
Concurrent treatment with inducers and inhibitors of CYP1A2 modulates CLZ elimination that disrupts therapy. Drug-drug interactions involving CYP3A4 are also significant but less predictable. To further characterise the factors underlying these interactions, we used samples from a cohort of human livers...
Among 66 adult schizophrenia patients treated with clozapine-based combination therapies, we explored the impact of genotype-predicted CYP1A2, CYP2D6, and CYP2C19 activity on dose-adjusted clozapine concentrations and symptom severity, with and without correction for inhibitors and inducers of these ...
ConclusionsThese observations support a central role for CYP1A2 in the in vivo disposition of tacrine and the potential for drug interactions when tacrine treated patients receive known inducers or inhibitors of this enzyme. The magnitude of the correlations we observed, however, are probably not ...