表 1 实验所用探针底物,抑制剂,诱导剂 Table 1 Probe substrates, inhibitors and inducers used in this study CYP 酶 体外探针底物 名称 浓度/(μmol·L−1) 体外阳性抑制剂 名称 浓度/(μmol·L−1) 体外阳性诱导剂 名称 浓度/(μmol·L−1) 体内探针底物 名称 给药量/(mg·kg−1) CYP1A2...
作为:酶的底物(substrates)(略),抑制剂(inhibitors),诱导剂(inducers) 酶的底物(substrates):具有特异型。我们重点讲解的是诱导剂。 CYP抑制和药物相互作用 多药联用治疗是一种常见的治疗方案,特别是对于那些有多病的病人中。理论上,如果两种药物被同时服用并竞争相同的CYP酶,药物的清除将受到阻碍,导致不可预料的...
最重要的是CYP3A4,约占全部药物的50% CYP2D6约占30% CYP2C9约占10% CYP1A2约占4% CYP2A6约占2% CYP2C19约占2% 酶的底物(Substrates) 抑制剂(inhibitors) 药酶活性减弱,使其他药物或本身代谢减慢,占代谢性相互作用的70% 诱导剂(inducers) 药酶活性增强,使其他药物或本身代谢加速,占代谢性相互作用的23% ...
Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver [J]. Drug Metab Dispos, 1999, 27(2): 188-192. [5] Edson KZ, Rettie AE. CYP4 enzymes as potential drug targets: focus onenzyme multiplicity, inducers and inhibitors, and therapeutic modulation...
作为:酶的底物(substrates)(略),抑制剂(inhibitors),诱导剂(inducers) 酶的底物(substrates):具有特异型。我们重点讲解的是诱导剂。 CYP抑制和药物相互作用 多药联用治疗是一种常见的治疗方案,特别是对于那些有多病的病人中。理论上,如果 两种药物被同时服用并竞争相同的CYP酶,药物的清除将受到阻碍,导致不可预料的...
P450 【四、影响P450酶活性的因素】[ CYP450氧化还原的遗传多态对药物代谢的影响,范岚,彭向东,郭志华,周宏灏] CYP450氧化还原的遗传多态对药物代谢的影响,范岚,彭向东,郭志华,周宏灏【五、药物与P450酶的关系】作为:酶的底物(substrates)(略),抑制剂(inhibitors),诱导剂(inducers) 酶的底物(substrates):具有特异...
saquinavir，indinavir CYP2D6CYP2E1 30%2% CYP3A4 50% 药物与CYP450酶的关系 酶的底物（Substrates）抑制剂（inhibitors）药酶活性减弱，使其他药物或本身代谢减慢,占代谢性相互作用的70% 诱导剂（inducers）药酶活性增强，使其他药物或本身代谢加速，占代谢性相互作用的23% P450酶的抑制 ...
Although many food ingredients such as caffeine, flavonoids, liquorice, spices, and vitamins are known to be inducers or inhibitors of some of the 57 known human CYP450 isoenzymes [cf. Flockhart Interaction Table, Drugbank, SuperCYP], they are not taken into account in the medicines' ...
medical orders of psychiatric inpatients from July 1 to December 31, 2018 in the First Hospital of Hebei Medical University was carried out, and ≥2 medical orders were used in combination to record the CYP450 enzyme substrates, inhibitors, or inducers were contained in the combined drug use. ...
Chineseherbs.,pharmaeokineticschangesoftalbutamimeand diazepamcausedbyextractofAngelicadahurica[J].JPharm Plaarnuteol,2000,52(8):1023-1029. [4]SlobodanR,FrederickJC.HumaneytoehromeP450enzymes:a statusreportsummarizingtheirreactions,substrates,inducers,and inhibitors[J].DmgMetabolRev,1997,29:413-...