它们通过与周期蛋白依赖性激酶(Cyclin-dependent kinase, CDKs)组成复合物,在细胞周期的不同阶段起着调控作用。Cyclin的表达受到细胞生长和环境刺激等因素的调节,其浓度的变化与细胞周期不同阶段的调节相关。 Cyclin A Cyclin A在细胞周期的S期(DNA复制阶段)和G2期(前期二阶段)表达并积累。在这些阶段,Cyclin A与CDK...
Cyclin A is the ONLY cyclin that plays a role in regulation of two cell cycle stages. It can activate two CDKs – CDK2 and CDK1. When Cyclin A forms a complex with CDK2, it allows the cell to progress to S phase. Meanwhile, binding of Cyclin A to CDK1 allows entry into M phase...
1. Malumbres, M. & Barbacid, M. Cell cycle, CDKs and cancer: a changing paradigm.Nature reviews. Cancer 9, 153-166, doi:10.1038/nrc2602 (2009).2. Kanie, T. et al. Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Molecular and cellular biology32, 59...
Kondorosi E, Athanasiadis A, Pongor S, Bako L, Koncz C, Gyorgyey J (1998) Cyclin dependent and calcium dependent kinase families: response of cell division cycle to hormone and stress signals. In: Francis D, Dudits D, Inzé D (eds) Plant cell division. Portland, Colchester, pp 21...
细胞周期蛋白依赖激酶(Cyclin-dependent kinases, CDKs)是一组丝氨酸/苏氨酸激酶,其催化活性可以受到细胞周期蛋白与CDK抑制剂的调节。CDK具有调节细胞周期检查点和DNA转录的作用,被认为对是细胞分裂增殖过程中的一类关键性的调控因子[1]。CDK通过响应多种胞内和胞外信号,与细胞周期蛋白形成异源二聚体调节细胞分裂。人类...
近日,陆军军医大学史春梦教授与中山大学孙逸仙纪念医院尹东研究员在Journal of Cell Biology发表研究论文Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle。该研究发现了Cyclin D1 mRNA...
细胞周期蛋白( Cyclin) ,细胞周期蛋 白依赖性激酶( CDKs) 和 CDK 抑制因子( CKIs) 是参与细胞周期调控的主要因子.Cyclin D1 是调控细胞周期 G1 期的关键蛋 白,是一个比其他 Cyclins 更加敏感的指标,对细胞周期调控至关重要.综述 Cyclin D1 的结构和功能及其在肿瘤组织中的表 达特征,初步分析 Cyclin D ...
Key words. Cell cycle controlcyclincyclin-dependent kinasesproteolysistumorigenesisCyclin A is particularly interesting among the cyclin family because it can activate two different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An embryonic form of cyclin A that is only ...
[3] Chotiner JY, Wolgemuth DJ, Wang PJ. Functions of cyclins and CDKs in mammalian gametogenesis[J]. Biol Reprod, 2019, 101(3): 591-601. DOI: 10.1093/biolre/ioz070. [4] Satyanarayana A, Kaldis P. Mammalian ...
Cdk2gamma-H2AXDNA double-strand breaksCdk activityCyclin A is a major regulator in vertebrate cell cycle, associated with cyclin-dependent kinase (Cdk), and involved in S-phase progression and entry into mitosis. It has been known that cyclin A overexpression not only causes premature S-phase ...