2021年1月,《自然通讯》发表了题为“CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells”的文章,阐述了抗CXCR5 CAR-T细胞的作用机理,即通过同时杀伤淋巴瘤细胞...
论文共同第一作者Mario Bunse博士解释说,“这两种类型的癌症不仅涉及B细胞,还涉及表面也携带CXCR5的辅助性滤泡T细胞。”靶向这种识别特征的特殊天线CXCR5-CAR是由Julia Bluhm博士在马克斯-德尔布鲁克分子医学中心转化肿瘤免疫学实验室作为博士生开发的,该实验室由医师Armin Rehm博士领导。他和Hoepken都是这篇论文的通讯作者...
本发明进一步涉及编码本发明的CAR的核酸分子,表达本发明的CAR的遗传修饰的免疫细胞,优选T细胞,以及所述细胞在治疗与表达CXCR5的致病性细胞的存在有关的医学病症中的用途,所述表达CXCR5的致病性细胞优选为致病性成熟B细胞和/或记忆B细胞和/或致病性T细胞和/或滤泡辅助性T细胞,特别是成熟B细胞非霍奇金淋巴瘤(BNHL),...
CAR T 细胞疗法是细胞重编程的一种高级形式,可将免疫细胞靶向肿瘤以治疗癌症。孤儿 GPRC5D 已被证明在骨髓瘤癌细胞中过度表达,并已成为称为 MCARH109 的嵌合抗原 T (CAR-T) 细胞疗法的靶标。溶瘤疱疹病毒 (oHSV) 被设计为通过将病毒与称为 oHSV/Nb-gD 的 CXCR4 纳米抗体融合来靶向 CXCR4+ 胶质母细胞...
ARTICLE https://doi.org/10.1038/s41467-020-20488-3 OPEN CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells Mario Bunse 1,7, Janina Pfeilschifter1,7, Julia Bluhm2, Maria Zschummel1, Jara J. Joedicke 1, Anthea Wirges2, ...
T cellsBackground: Solid tumors are characterized by a low blood supply, complex stromal architecture, and immunosuppressive milieu, which inhibit CAR-T cell entry and survival. CXCR5 has previously been employed to increase CAR-T cell infiltration into CXCL13 cancers. On ...
CXCR5-CAR Tregs activated by anti-CD3/CD28 beads showed suppressive function to responder naïve T cell proliferation. This effect was comparable to that of UT Tregs, exhibiting slightly a more inhibitory function at the Treg:cTfh cell ratio of 1:10 (Figure 1E). These results suggest that ...
Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study Yunyu Mao Qibin Liao Jianqing Xu Cell Discovery (2024) FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR ...
functional role ascribed to Gi heterotrimeric G-proteins is to link chemoattractant chemoattractant receptors receptors gtouiddoewthnestrreecarmuietmffeecntto,rtsrathffaictkminegd,iaanteddtihreecpteodsitcieolnl imngigorafttihoynm1.oNcuymteserionutshGe tihliynmkeuds and T cells in lymphoid organs2...
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection PLoS Pathog., 5 (2009), p. e1000295, 10.1371/journal.ppat.1000295 View in ScopusGoogle Scholar Ferlazzo and Carrega, 2012 G. Ferlazzo, P. Carrega Natural killer cell distribution and traffi...