最近,圣犹大儿童研究医院的研究人员发现了一种改进 CAR-T 细胞疗法的方法,该方法能增强 T 细胞定位并攻击骨肉瘤的能力。这项研究提高了 CAR-T 细胞找到并进入肿瘤部位的效率,这对于设计更有效的 CAR-T 细胞疗法至关重要。 相关研究结果于2024年8月5日在线发表在Clinical Cancer Research期刊上,论文标题为“Redirec...
最近,圣犹大儿童研究医院的研究人员发现了一种改进 CAR-T 细胞疗法的方法,该方法能增强 T 细胞定位并攻击骨肉瘤的能力。这项研究提高了 CAR-T 细胞找到并进入肿瘤部位的效率,这对于设计更有效的 CAR-T 细胞疗法至关重要。 相关研究结果于2024年8月5日在线发表在Clinical Cancer Research期刊上,论文标题为“Redirec...
这项研究提高了 CAR-T 细胞找到并进入肿瘤部位的效率,这对于设计更有效的 CAR-T 细胞疗法至关重要。 相关研究结果于2024年8月5日在线发表在Clinical Cancer Research期刊上,论文标题为“Redirecting B7-H3.CAR T cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor...
T cellsCHIMERIC antigen receptorsCYTOTOXIC T cellsIMMUNOLOGIC memoryTUMORSANIMAL models in researchPANCREATIC cancerChimeric antigen receptor (CAR) T-cell therapy targeting solid tumors has stagnated as a result of tumor heterogeneity, immunosuppressive microenvironments, and inadequate intratumoral T cell ...
Specifically, targeting of CXCR2 has resulted in suppression of inflammatory skin and intestinal tumorogenesis14, reduced spontaneous adenocarcinoma for- mation in the intestine14, decreased acute myeloid leukemia15, inflammatory bowel disease16, nasopharyngeal car- cionoma17 and rhabdomyosarcoma (in ...
检测或靶向特定的 CD8 + T 细胞亚群是CAR-T免疫疗法成功的关键。例如,几项研究表明,具有干细胞样特征的早期分化T细胞亚群,即具有长期存在和发挥效应功能,是过继回输后肿瘤消退的原因。 高维流式细胞仪能以高通量方式剖析记忆 T...
An EnVision kit (DAKO, Carpinteria, CA, USA) was used to detect the primary antibodies followed by 3, 3-diaminobenzidine substrate visualization and counterstaining with haematoxylin. The intensity of IHC staining in the tumour cells was scored independently by two pathologists using the semi...
To assess the utility of the dual CAR we determined that canine OS cell lines secreted high IL8 spontaneously. To assess the functionality of canine B7-H3 CAR T cells, we generated canine CAR T cells from whole blood from dogs with cancer. We next determined that canine dual CAR T cells ...
CAROFF, EVAKELLER, MARCELKIMMERLIN, THIERRYMEYER, EMMANUEL
CAROFF, EVAKELLER, MARCELKIMMERLIN, THIERRYMEYER, EMMANUEL