尽管 Tem 通常缺乏 CD27 和 CD28 的表达,但在一些报告中显示,外周血 CD8 + T 细胞亚群在表型上介于 TSCM/CM 和 Tem 之间,被称为过渡记忆(T TM细胞),这些细胞在 HIV 特异性 CD8 + T 细胞中特别多见,其CCR7 和 CD62L 下调,但仍表达 CD27 和/或 CD28。 随着人类年龄的增长,效应记忆 CD8 + T 细胞...
此外,最近发现,CCR7+ CD95– CD45RA+ 初始CD8 细胞仍然表现出异质性迹象,因为CXCR3的表达能识别初始CD8 T细胞是否有更高的分化为效应细胞的潜力,这有助于为免疫治疗方法(例如,CAR-T 细胞疗法)获得更有效的效应细胞。由于冷冻...
While all patients progressed and were switched to alternative therapy, we observed a significant association between good CAR-T expanders and expression of C-X-C Motif Chemokine receptor 3 (CXCR3) on monocytes detected in pretreatment apheresis. This study seeks to uncover the possible interactions...
Furthermore, SCD increased the secretion of the C–X–C motif chemokine ligand 11 (CXCL11) from CD4+ T cells. The binding of CXCL11 to CXCR3 on CD8+ T cells augmented their cytotoxic activity. In a mouse tumor model, the suppressive effect of CD8+ T cells on tumor growth was ...
Cancer Immunology, Immunotherapy (2023) 72:1461–1478 https://doi.org/10.1007/s00262-022-03338-7 RESEARCH Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate Adam L. Burrack1,2 · Ellen J. Spartz1,2 · Meagan R. Rollins1,2 · Ebony A...
Various adhesion molecules have been implicated in T lymphocyte binding to dermal vascular endothelium in psoriasis vulgaris, but the chemotactic signals that promote subsequent homing into the adjacent dermis and overlying epidermis are poorly defined.
doi:10.1016/j.cancergencyto.2010.07.080Teresa San MiguelRobert CallaghanSandra PintoAlicia MartínezConcha López-GinésAna Pellín-CarcelénCarmen CardaMiguel Cerdá-NicolásAntonio Llombart-BoschRosario Gil-BensoElsevier Inc.Cancer Genetics & Cytogenetics...
检测或靶向特定的 CD8 + T 细胞亚群是CAR-T免疫疗法成功的关键。例如,几项研究表明,具有干细胞样特征的早期分化T细胞亚群,即具有长期存在和发挥效应功能,是过继回输后肿瘤消退的原因。 高维流式细胞仪能以高通量方式剖析记忆 T 细胞的异质性。在这里,我们回顾了最能定义人类常规 αβ CD8 + T 细胞异质性的细...
CAROFF, EVAKELLER, MARCELKIMMERLIN, THIERRYMEYER, EMMANUEL
CAROFF, EVAKELLER, MARCELKIMMERLIN, THIERRYMEYER, EMMANUEL