本研究旨在克隆小鼠CXCR3A基因并将其转入不表达该分子的小鼠黑色素瘤细胞B16中,在体内外研究B16-mCXCR3A细胞的迁移能力和致瘤性。同时克隆人CXCR3B基因,并建立稳定表达人CXCR3B分子的基因转染细胞株L929-huCXCR3B,为制备相应的单克隆抗体奠定了物质基础。第一部分小鼠CXCR3A基因的克隆及基因转染细胞株
CXCR3 is expressed on activated T cells and plays a crucial role in T-cell recruitment to the tumor microenvironment (TME) during cell-based and immune checkpoint inhibitor (ICI) immunotherapy. This study utilized a 64Cu-labeled NOTA-α-CXCR3 antibody to assess CXCR3 expression in the TME an...
目前,趋化因CXCL10子及其受体CXCR3调控HSC功能和稳态的作用和机制尚未被完全阐明。 2024年8月7日,来自广东省人民医院曾辉、暨南大学附属第一医院杜鹃团队在Stem Cell Research & Therapy杂志上发表了题为Cxcl10 and Cxcr3 regulate self-re...
CXCR3 ELISA试剂盒是科研常备工具,用于检测CXC趋化因子受体3含量。该试剂盒采用双抗夹心法,适用于血浆、唾液、尿液等多种样本,操作简便且结果准确。现在店内瑞清品牌试剂盒,有效期长达6个月,辣根过氧化物酶标记,确保性能稳定。且支持定制,满足小鼠、大鼠、植物等多种种属检测需求。顺丰包邮,现货供应,深圳产地,质量有...
The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of ...
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产品名称: 人CXC趋化因子受体3(CXCR3)ELISA试剂盒 产品规格: 96T/48T 检测方法: elisa试剂盒 样本: 血清 细胞上清 组织匀浆尿液 保质期: 6个月 储存条件: 2-8℃冷藏 用途范围: 仅供科研实验 是否进口: 否 英文名称: Human CXC-chemokine receptor 3, CXCR3 Elisa Kit 包装: 盒装液体 运输...
Seven transmembrane segment (7TM) receptors are activated through a common, still rather unclear molecular mechanism by a variety of chemical messengers ranging from monoamines to large proteins. By introducing a His residue at position III:05 in the CXCR3 receptor a metal ion site was built bet...
CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes the recruitment of T-lymphocytes and other immune cells to the inflammatory site in response to the binding of cognate chemokines. Upregulation of CXCR3 and its chemokines has been found during athero...
Protein expression of CXCR3 and cytotoxic molecules were similarly increased in the different stages of the disease. However, CLL-B patients displayed an increased percentage of CD4+ T cells expressing PD1 (around 7% in MBL and CLL-A versus 16% in CLL-B), although significance was not ...