趋化因子受体CXCR5是CAR-T细胞治疗的一个卓越靶点,因为CXCR5表达于成熟B细胞、恶性B细胞和肿瘤辅助性滤泡T辅助细胞(Tfh)上,而在骨髓内的B细胞前体或浆细胞上不表达。2021年1月,《自然通讯》发表了题为“CXCR5 CAR-T cells simultan...
CXCR5-deficient B cells fail to access inflamed B cell follicles.Cyrille, MionnetIsabelle, MondorAudrey, JorqueraMarie, LoosveldJulien, MaurizioMarieLaure, ArcangeliNancy, H. RuddleJonathan, NowakMichel, AurrandLionsHervé, Luche
CD8 Tfh cells share similar gene signatures with CD4 Tfh, and require CD40L/CD40 and TCR/MHCI interactions to deliver help to B cells. Our study thus highlights the diversity of follicular T cell subsets that contribute to the breakdown of B-cell tolerance....
图5| CXCR5+CD8+ T cells exhibit greater therapeutic potential than CXCR5-CD8+ T cells in the control of chronic viral infection. a, b, Equal numbers of CD44hiCXCR5+ or CD44hiCXCR5-CD8+ T cells sorted from day 8 Cl13-infected mice were adoptively transferred into Cl13-infected CD4+ T ...
In Chronic Lymphocytic Leukemia (CLL), infiltration of lymph nodes by leukemic cells is observed in patients with progressive disease and adverse outcome. We have previously demonstrated that B-cell receptor (BCR) engagement resulted in CXCR4 down-regulation in CLL cells, correlating with a shorter...
Background:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles...
It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been ...
Tonsillar CXCR5+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follic...
Tonsillar CXCR5+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell foll...
CXCR5主要表达在成熟的B细胞及滤泡辅助T细胞中,CXCL13/CXCR5信号途径的非正常激活影响肿瘤细胞转移、浸润,同时也与系统性红斑狼疮及类风湿关节炎等自免疾病相关[2]。靶向抑制CXCR5主要应用于治疗转移型肿瘤及自免疾病等。 CXCR及其配体[6] CXCL12/CXCR4/CXCR7信号通路[7] ...