Abstract:ObjectiveTo explore the expression of CXCR4 in human gastric cancer tissue and its clinical significance.MethodsCXCR4 expression was detected in 30 normal gastric cancer tissues adjacent to cancer lesion,86 primary lesions of gastric cancer including 8 peritoneal metastases foci and 60 metastati...
(C-X-C motif) receptor 4; chemokine receptor; CXC; CXC motif chemokine; CXC-R4; FB22; Fusin; HM89; HUMSTR; LAP-3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide...
CXCR4is one of 19 humanchemokine receptorsand is activated by the large peptide ligand SDF-1 (CXCL12). The primary role ofchemokinesand their receptors is in leukocyte trafficking to sites of inflammation as well as cell homing and patterning during development. CXCR4 is of particular interest ...
Applications Tested: This 2B11 antibody has been tested by flow cytometric analysis of mouse thymocytes. This may be used at less than or equal to 1.0 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. ...
Valenzuela-FernándeA,PlanchenaultT,BaleuxF,et al.Leukocyte elastase negatively regulates Stromal cell-derived factor-1(SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4[J].J Biol Chem,2002,277(18):15677-15689.DOI:10.1074/jbc.M111388200. ...
MPO activity, as a marker of local leukocyte sequestration, was also examined in this study. Figure2Dshows that colonic MPO activity was significantly increased 7 d after induction of colitis; treatment with AMD3100 decreased the colonic MPO level. These findings indicated that AMD3100 could inhibit...
Valenzuela-FernándeA,PlanchenaultT,BaleuxF,et al.Leukocyte elastase negatively regulates Stromal cell-derived factor-1(SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4[J].J Biol Chem,2002,277(18):15677-15689.DOI:10.1074/jbc.M111388200. ...
(SDF-1α) is lethal, it was originally hypothesised that CXCR4 played an important role in the homeostatic homing mechanism of multiple leukocyte populations. Therefore, it was surprising that blockade of thischemokine receptorwith a blockingmonoclonal antibodycaused a significant reduction in both ...
(WHIM) syndrome is a rare, combined immunodeficiency disease predominantly caused by gain-offunction variants in the CXCR4 gene that typically results in truncation of the carboxyl terminus of C-X-C chemokine receptor type 4 (CXCR4) leading to impaired leukocyte egress from bone m...
Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the curren...