However, it is unclear how modulation of neutrophil CXCR4 signaling is linked to their migration toward the vascular endothelium and subsequent entry into the circulation. Therefore, the question of whether neutrophil egress from the bone marrow is a passive, random process or actively directed and ...
Neutrophils express CXCR1 and CXCR2 receptors, which bind IL-8 and this mediates neutrophil tissue recruitment. In addition to the predominant expression of CC chemokine receptors, eosinophils, basophils, and mononuclear cells express the CXC chemokine receptor CXCR4, which is also expressed on neutr...
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target. However the success of the therapeutic targeting of CXCR2 is threatened by our...
CXCL2 is a powerful chemoattractant for neutrophils and a previous publication has shown that neutrophil extracellular traps can promote tumor cell metastasis to the liver [30]. In fact, a recent study suggested that neutrophil extracellular traps enhance peritoneal spread of gastric cancer cells [31...
Pancreatic ductal adenocarcinoma (PDAC) is considered non-immunogenic, with trials showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we sought to systematically characterize the mechanisms underlying de novo ICT resista
(e.g., CXCR4, receptor for stromal cell-derived factor-1), receptors for lipid mediators (e.g., the cysteinyl leukotriene receptor cysLT1 and the ... R Möhle,F Bautz,C Denzlinger,... - 《Annals of the New York Academy of Sciences》 被引量: 171发表: 2001年 Neutrophil arrest by...
There was no neutrophil in the luminal epithelium on Day 4, but in endometrium stroma there were a lot of neutrophils. On Day 5 and Day 6, the amout of neutrophils was greatly small in the stroma and no one was seen in the luminal epithelium. Conclusion: CXCR2 might take part in the...
Fig. 2.CXCR2 increases neutrophil recruitment at the site of infection, which enhances the importance of neutrophil CXCR2 during sepsis. While activated neutrophils express CCR2 during severe sepsis, they lose responsiveness toCXCR2ligands by receptorinternalization, and this change is critical for neu...
Using Cxcr2 knock-out mice, we have evaluated the function of the chemokine receptor Cxcr2 in neutrophil physiology. We show here that Cxcr2 deficiency decreases the percentage of mature neutrophils in the spleen, but not in the bone marrow (BM). There is also an incr...
Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with...