Extracellular acidosis promotes neutrophil trans- differentiation to MHC class II-expressing cells. Cell Immunol. 2011;271:214-8.Pliyev, B. K., Sumarokov, A. B., Buriachkovskaia, L. I., Menshikov, M. (2011) Extracellular acidosis promotes neutrophil transdifferentiation to MHC class II-...
Among 20 amino acids screened, leucine correlated best with the HLA-DR+CD74+ signature, augmented the mitochondrial oxygen consumption rate and enhanced H3K27ac and expression of genes involved in assembly of major histocompatibility complex class II (MHC-II), antigen processing and loading. HLA-...
histocompatibility complex (MHC) class II molecules for antigen presentation, such asH2-Ab1(Fig.1D, Table1). Table 1 Immune-related differentially expressed genes identified through RNA-Seq of endothelial cells isolated fromCcm3iECKOmice during acute and chronic CCM, along with some of their functio...
Intratracheal infection with pneumococcus increases the level of murine MHC class II in cell-free BALF To confirm whether NE induces cleavage of MHC class II in vivo, we investigated the effect of NE on BALB/c mice upon intratracheal infection with pneumococcus in the presence or absence of SS...
neutrophils serve as an APC. Neutrophils cross-prime CD4+T cells via MHCII and cross-present to CD8+T cells via MHCI. G-CSF can induce suppressor IL-10+neutrophils to promote regulatory T cells (Treg). In addition, neutrophils also interconnect with other immune cells such as suppressive mac...
Our data showed that antibody therapy composed of nonfucosylated rituximab can activate human neutrophil functions involving phagocytosis and MHC class II expression, which may favorably potentiate the adaptive immune response in cancer patients.Previous...
[137]. Neutrophils cultured in the presence of autologous serum, IFN-γ and GM-CSF expresses high level of MHC class II,CD80and CD86 molecules[138]. This makes them efficientAPCs, which are capable of inducing strong T cell immune response against antigen in a MHC class II–restricted ...
Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice. We have introduced the class II E alpha d gene into (C57BL/6 X SJL) F2 mice which do not express their endogenous E alpha gene. The mRNA expression of the ... C A,Pinkert,...
et al. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc. Natl. Acad. Sci. USA (pp. 1122–1131) (2013). Google Scholar Faust, N., Varas, F., Kelly, L. M., Heck, S...
Some even expressed MHC class II molecules, indi- cating that GM-CSF can drive DC-like differentiation of NeuPs in a manner similar to its effects on neutrophils. However, G-CSF had no such effect on neutrophils or NeuPs (Fig. 3e). Interestingly, overall survival was better with GM-...