Extracellular acidosis promotes neutrophil trans- differentiation to MHC class II-expressing cells. Cell Immunol. 2011;271:214-8.Pliyev, B. K., Sumarokov, A. B., Buriachkovskaia, L. I., Menshikov, M. (2011) Extracellular acidosis promotes neutrophil transdifferentiation to MHC class II-...
Intratracheal infection with pneumococcus increases the level of murine MHC class II in cell-free BALF To confirm whether NE induces cleavage of MHC class II in vivo, we investigated the effect of NE on BALB/c mice upon intratracheal infection with pneumococcus in the presence or absence of SS...
et al. Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome. J. Cell Biol. 141, 1121–1134 (1998). CAS PubMed PubMed Central Google Scholar Introne, W., Boissy, R. E. & Gahl, W. A. Clinical, molecular...
Neutrophils express most of the toll-like receptor (TLR) family members, MHC class II, CD80, and CD86, and present antigens to T cells and can prime antigen-specific Th1 and Th17 differentiation.1,2 Indeed, neutrophils have been demonstrated to migrate toward inflammation sites, and then “...
Besides expressing MHC class I and II molecules, human peripheral blood neutrophils also express other accessory molecules called B7-1 like molecule constitutively which interacts with CD28 expressed on T cells [140]. This interaction between CD28 and B7-1 augments IFN-γ secretion by T cells [...
appreciated that neutrophils are capable of cross-priming CD4+T cells via major histocompatibility complex II (MHCII) and cross-presenting to CD8+T cells via MHCI, suggesting that neutrophils could also serve as antigen-presenting cells (APCs) [99,100] (Fig.3). Specifically, after interferon (...
(Supplemental Fig. 6). Some of the DAPI+CD45+leukocytes detected in CCM lesions were positive for MHC class II (Fig.5B). Furthermore, polymorphonuclear neutrophils, F4/80+macrophages, and B220+B cells were also seen in the CCM lesions (Fig.5C–E, respectively), but not in the ...
Further, synovial cells in patients with RA are known to aberrantly express MHC class II molecules and to act as antigen-presenting cells [34-36]. Thereby the increase of cathepsin D may promote immune reaction in the joints. Cathepsin D is associated with the proliferation, inva- sion and ...
(such as LL-37), and lactoferin, which can either directly participate in microorganism killing or trigger other components of the innate or adaptive immune response. Neutrophils express most of the toll-like receptor (TLR) family members,MHC class II,CD80, andCD86, and present antigens toT ...
A class II major histocompatibility complex (MHC) molecule, DPB1*0401, was strongly associated with GPA in two studies.51,52 The HLA-DR4 allele also has been associated with susceptibility to AAV.53,54 Single-nucleotide polymorphisms associated with T-cell activation, the IL-2 receptor, CTLA-...