Weaknesses of the zebrafish model include the relatively low-throughput and limited spatial and temporal resolution imposed by the requirement for high-magnification (limited field of view), multichannel, z-stack, and multi-animal time-lapse imaging for these types of experiments. Additionally, the la...
et al. Structured nucleosome fingerprints enable high-resolution mapping of chromatin architecture within regulatory regions. Genome Res. 25, 1757–1770 (2015). Article PubMed PubMed Central CAS Google Scholar Janssen, A., Colmenares, S. U. & Karpen, G. H. Heterochromatin: guardian of the ...
However, traditional workflows for imaging individual larvae have been limited to low-throughput studies using traditional microscopes and manual analyses. Using a newly developed, parallelized microscope, the Multi-Camera Array Microscope (MCAM), we have optimized a rapid, hi...
However, when taken together into a logistic model, they allowed for predicting CVS with high sensitivity (91 %) and specificity (79 %). MPO and ELA, along with other clinical parameters, can be used as early predictors of CVS in aSAH patients and can serve as guidance during treatment ...
Multilevel omics integration reveals high expression of FOXO1 in the acute stage following TBI.aUMAP embedding of the entire dataset colored by orthogonally generated clusters labeled by manual cell type annotation, which were the scRNA-seq data analysis for peripheral blood samples from healthy donors...
Multilevel omics integration reveals high expression of FOXO1 in the acute stage following TBI. a UMAP embedding of the entire dataset colored by orthogonally generated clusters labeled by manual cell type annotation, which were the scRNA-seq data analysis for peripheral blood samples from healthy don...
(E) Effect of TNFA treatment on CXCL8 expression in EndoC-H1 cells cultured under high-palmitate (0.5 mM) and glucose (25 mM) conditions (pal&glu). Data are mean ± SEM. n = 6/group, one-way ANOVA followed by Tukey’s multiple comparisons test; ∗∗∗p < 0.001. (F) Effect...
High levels of arginase mainly correlated with reduced levels of inducible nitric oxide synthase (iNos), according to the reciprocal regulation of the arg-1 and iNos pathways, which both use L-arginine as a substrate30. To ensure that arginase was effectively derived from blood clot-activated ...
(R-type VGCC) is the primary type of VGCC expressed in neutrophils. These results suggest that F-ATPase may form a protein complex with Cav2.3 via interactions with auxiliary α2δ-1 subunits. Cav2.3 channels are high-threshold voltage-gated channels, and the activation potential of Cav2.3 ...
The above data analysis of the samples collected demonstrates that the present specification has high levels of correlation, sensitivity and specificity in comparison to the manual differential inspection of the samples. Novel and non-obvious reporting processes further make the data analysis easier for ...