Multilevel omics integration reveals high expression of FOXO1 in the acute stage following TBI. a UMAP embedding of the entire dataset colored by orthogonally generated clusters labeled by manual cell type annotation, which were the scRNA-seq data analysis for peripheral blood samples from healthy don...
However, when taken together into a logistic model, they allowed for predicting CVS with high sensitivity (91 %) and specificity (79 %). MPO and ELA, along with other clinical parameters, can be used as early predictors of CVS in aSAH patients and can serve as guidance during treatment ...
et al. Structured nucleosome fingerprints enable high-resolution mapping of chromatin architecture within regulatory regions. Genome Res. 25, 1757–1770 (2015). Article PubMed PubMed Central CAS Google Scholar Janssen, A., Colmenares, S. U. & Karpen, G. H. Heterochromatin: guardian of the ...
In addition, we demonstrate that high levels of IL-17a were present in GC tissues and that neutrophils produced IL-17a. In an in vitro experiment, we observed that IL-17a secreted by TANs plays an important role in the progression of GC. TANs-derived-IL-17a promoted the migration, ...
DDX58, STAT2, ISG15, ISG20, OASL2, and CXCL10, there was high correlation between microarray and RT-PCR data (0.96, 0.90, 0.86, 0.93, 0.95, and 0.95, respectively). For all infections, RT-PCR detected overexpression of IRF1 especially at 3 h p.i., and of IRF7 and IRF9 later ...
High levels of arginase mainly correlated with reduced levels of inducible nitric oxide synthase (iNos), according to the reciprocal regulation of the arg-1 and iNos pathways, which both use L-arginine as a substrate30. To ensure that arginase was effectively derived from blood clot-activated ...
(R-type VGCC) is the primary type of VGCC expressed in neutrophils. These results suggest that F-ATPase may form a protein complex with Cav2.3 via interactions with auxiliary α2δ-1 subunits. Cav2.3 channels are high-threshold voltage-gated channels, and the activation potential of Cav2.3 ...
The fact that the severe course of sepsis could be prevented by the presence of sufficiently high acetate concentrations in serum at the time point ofS. aureusentry into the bloodstream raised the question, whether an interventional application of acetate after infection onset could still help to tr...
The above data analysis of the samples collected demonstrates that the present specification has high levels of correlation, sensitivity and specificity in comparison to the manual differential inspection of the samples. Novel and non-obvious reporting processes further make the data analysis easier for ...
However, traditional workflows for imaging individual larvae have been limited to low-throughput studies using traditional microscopes and manual analyses. Using a newly developed, parallelized microscope, the Multi-Camera Array Microscope (MCAM), we have optimized a rapid, hi...