The article discusses research being done on the roles of CTCF-binding sites (CBSs). It references the paper "CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function" by Y. Guo et al., published in a 2015 issue of the journal "Cell." The research showed the ...
for the glucocorticoid receptor (GR), differences as small as one nucleotide base among the endogenous GR binding sites can have a dramatic impact on GR conformation and activity [15]. Thus, binding sites play an important role in determining function. Using genome-wide location analysis, a majo...
CTCF-binding sites are shaped by natural selection and ... their alteration influences gene expression patterns The authors mapped the binding sites of CTCF inDrosophila melanogasterand three other species ofDrosophila:Drosophila simulans,Drosophila yakubaandDrosophila pseudoobscura, which are separated fromD...
The CTCF-binding Sites in Herpes Simplex Virus-II Display Promoter-blocking Activity CTCF-binding motifs are located in the LAT downstream and intron, and display promoter-blocking activity that may play an important part in HSV-2 latency... H Yang 被引量: 0发表: 0年 A Chromatin Insulator-...
We have comprehensively characterized these three classes of CTCF sites with respect to several evolutionary, genomic, epigenomic, transcriptomic and functional features. We find that the low- occupancy sites tend to be cell type specific. Furthermore, while the high-occupancy sites associate with ...
Here, we describe recent updates to a database of CTCF-binding sites, CTCFBSDB (http://insulatordb.uthsc.edu/), which now contains almost 15 million CTCF-binding sequences in 10 species. Since the original publication of the database, studies of the 3D structure of the genome, such as ...
(Supplementary Fig.12). We would expect mutations at these hotspots to be associated with expression change of the altered allele. However, allele-specific expression analysis is challenging to evaluate across distant sites. Indeed, for all three candidate CBS hotspots, we could not unambiguously ...
文档分类: 论文--期刊/会议论文 文档标签: saimirictcfherpesviruslanaepisomallatently 系统标签: saimirictcfherpesviruslanaepisomallatently TheInsulatorProteinCTCFBindingSitesintheorf73/LANA PromoterRegionofHerpesvirusSaimiriAreInvolvedinConferring EpisomalStabilityinLatentlyInfectedHumanTCells KatrinZielke,FlorianFull,Nata...
Genome-wide Mapping of CTCF-binding Sites Many genome-wide studies have revealed tens of thousands of CTCF-binding sites and shed light on its functions (27, 28, 29). An initial study in mouse fetal liver using ChIP-chip found >200 methylation-free CTCF-binding sites, many of which functio...
CTCF-binding sites that are conserved among these species but were previously undetected. In particular, this program identified CTCF-binding sites that are located close to the Dlk1, Magel2 and Cdkn1c imprinted genes. Individual ChIP experi- ments confirmed the in vivo binding of the YY1 and ...