However, hitherto there is no comprehensive survey of genome-wide CTCF binding patterns across different human cancers. Results: To dissect functions of CTCF binding, we systematically analyze over 700 CTCF ChIP-seq profiles across human tissues and cancers and identify cancer-specific CTCF binding ...
We have classified approximately 26,000 CTCF binding sites in CD4+ T cells into three classes based on their similarity to the well-characterized CTCF DNA-binding motif. We have comprehensively characterized these three classes of CTCF sites with respect to several evolutionary, genomic, epigenomic, ...
While the orientation of CTCF motifs determines which pairs of CTCF sites preferentially stabilize loops, the molecular basis of this polarity remains unclear. By combining ChIP-seq and single molecule live imaging we report that CTCF positions cohesin, but does not control its overall binding ...
CTCFBindingtotheFirstIntronoftheMajorImmediateEarly (MIE)GeneofHumanCytomegalovirus(HCMV)Negatively RegulatesMIEGeneExpressionandHCMVReplication FranciscoPuertaMartínez, a RuthCruz, a FangLu, b RobertPlasschaert, c ZhongDeng, b YiselA.Rivera-Molina, a MarisaS.Bartolomei, c PaulM.Lieberman, b QiyiTang...
(P0.001),but did not silenced luciferase gene expression compared with pGL3-bisace.The pGL3-promoter-CTUL group showed a significant difference compared with the pGL3-promoter group(P0.05).CTCF-binding motifs are located in the LAT downstream and intron,and display promoter-blocking activity that ...
A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms’ tumourigenesis71阅读 文档大小:906.84K 12页 Science上传于2015-06-17 格式:PDF ncb3499-ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of...
ctcf binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic featuresctcf绑定网站类展览不同的进化,基因、外遗传性和转录组的功能.pdf,Volume 10, Issue 11, Article R131et al.Essien2009 Open Access Research CTCF binding site
展开 关键词: 3C-HTGTS CBE orientation CTCF-binding elements HTGTS-Rep-seq RAG chromatin scanning V(D)J recombination V(H) accessibility V(H)81X intergenic control region 1 loop extrusion DOI: 10.1016/j.cell.2018.04.035 被引量: 5 年份: 2018 收藏...
CTCF is a highly conserved transcriptional regulator protein that performs diverse functions such as regulating gene expression and organizing the 3D structure of the genome. Here, we describe recent updates to a database of CTCF-binding sites, CTCFBSDB (http://insulatordb.uthsc.edu/), which now...
17q21 asthma-risk SNPs switch CTCF-binding sites We performed anin silicoanalysis to identify the transcription factors whose binding to thecis-regulatory regions described above is perturbed by asthma-risk SNPs. Our evaluation pointed to perturbation of two CTCF-binding motifs as well as motifs of...