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Chemical Name: CSF1R-IN-1 Synonyms CSF1R-IN-1;CSF1R-IN-22;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide;3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-;Inhibitor,inhibit...
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This study aims to investigate the treatment effects of a new CSF-1R inhibitor named C019199 in murine breast cancer (BC) models when administered alone or in combination with anti-PD-1 antibody. Methods Inhibition of CSF-1R was investigated in the murine bone marrow derived macrophages (BMDMs...
化合物 CSF1R-IN-4 CAS号: 2716185-86-1 英文名: 3-Pyridinecarboxamide, 1-cyclopropyl-1,2-dihydro-N-[5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-oxo- 英文别名: CSF1R-IN-4;3-Pyridinecarboxamide, 1-cyclopropyl-1,2-dihydro-N-[5-[[2-(1-methyl-1H-pyrazol-...
Analysis of the CSF-1/CSF-1R pathway uncovered that CSF-1 was significantly higher in serum from grade 3A FL patients, and that high CSF-1R expression in FL biopsies correlated with grade 3A, reduced overall survival and risk of transformation. Furthermore, CSF-1R inhibition with pexidartini...
Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM. 靶点活性 NAMPT:3.1 nM, CSF1R:0.84 μM 体外活性 LSN3154567 inhibits purified NAMPT with an IC50 of 3.1 nM. When tested against a panel of human kinases (>100; CEREP Kinase panel), it does not exhibit any significant activity ...
Synonyms: CSF1R-IN-1 CSF1R-IN-22 3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]- 5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony ...
Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neuron.s in mice. Wang Y,Berezovska O,Fedoroff S. Journal of Neuroscience Research . 1999Wang YQ, Berezovska O, Fedoroff S.Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in Mice [J]...
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet 2012;44:200-5.Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, Adamson J...