文献54-早期长期使用CSF1R抑制剂PLX3397可以清除小胶质细胞,并减少5XFAD小鼠阿尔茨海默病模型中神经元内淀粉样蛋白的积累、神经元斑块的沉积以及前纤维化寡聚物的形成 文章题目:Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neur...
PLX5622 in AIN-76A Diet (1200 ppm) 是研究健康/疾病状态下小胶质细胞功能 (microglia function resea...
Microglia from the hippocampus and the somatosensory cortex (SSC) of 5XFAD mice receiving a diet containing either the CSF1R inhibitor PLX5622 or a standard diet for ten days were examined for morphology, markers of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome ...
However, microglia are required to maintain healthy brain homeostasis and as such, complete microglia depletion may not be a viable therapeutic strategy. Therefore, in the present study we examined the effect of CSF1R inhibitor-mediated microglia depletion on α-syn aggregation and neurodegeneration ...
CSF1R inhibitor abrogates tau propagation exacerbated in APPNL‐G‐F knock‐in mice but enhances fibrillar beta‐amyloidosis and dystrophic neurite formation in the brainMicroglia are the primary innate immune cells in the brain. They can phagocytose apoptotic neurons and dystrophic neurites containing...
The small molecule PLX5622, a highly selective inhibitor of CSF1R kinase, has been used to deplete microglia and, thereby, alter energy intake and expenditure in high-fat-diet (HFD)-fed mice [9, 10]. Recent data suggest that the effect of PLX5622 is not restricted to microglia and that...
An alternative strategy is to target cells in the glioma microenvironment, such as tumor-associated macrophages and microglia (TAMs). Macrophages depend on colony stimulating factor-1 (CSF-1) for differentiation and survival. We used an inhibitor of the CSF-1 receptor (CSF-1R) to target TAMs ...
Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622) allowing for extended and specific microglial elimination, preceding and during pathology development. We find ...
Microglia play a pivotal role in regulating myelination processes, and the colony-stimulating factor 1 (CSF-1) pathway is a key regulator for microglia differentiation and survival. Here, we investigated the effects of the CSF-1 receptor kinase inhibitor, BLZ945, on central myelination processes ...
selective CSF-1R inhibitor, which penetrates the blood-brain barrier (BBB), to block CSF-1R signaling in glioma as illustrated in the RCAS-PDGF-B-HA/Nestin-Tv-a; Ink4a/Arf−/−mouse model of gliomagenesis. This genetically engineered glioma model is ideal for preclinical testing as a ...