2.Recent advances of colony-stimulating factor-1 receptor (CSF-1R) kinase and its inhibitors（2018）3.CSF-1R Inhibitor Development: Current Clinical Status（2017）4.Safety, Tolerability, and Efficacy of Axatilimab, a CSF-1R humanized antibody, for Chronic Graft-versus-Host Disease after 2 or ...
12 June 2023, Shanghai – Abbisko Therapeutics Co., Ltd. (“Abbisko Therapeutics”hereafter) today announced that the first patient has been dosed in the phase II trial evaluating its CSF-1R inhibitor, Pimicotinib (ABSK021), in patients with cGVHD. The primary underlying mechanism of cGV...
研究计划入组约90例受试者,主要终点是基于盲态的独立评审委员会(BIRC)评估的25 周客观缓解率(ORR)。 Abbisko Therapeutics Completed All Patient Enrollment for The Global Phase III TGCT Trial of Its CSF-1R Inhibitor – Pimicotinib(ABSK021) 9 April 2024, Abbisko Therapeutics Co., Ltd. (Abbisko Thera...
[6] Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal p...
1#Breast cancer study uncovers how macrophages may contribute to a therapeutic weak spot(来源:Dana-Farber Cancer Institute) 2#Anita K. Mehta et al. Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Nature Cancer (2020)....
Abbisko Therapeutics Completes the First Patient Dose in the Phase II Advanced Pancreatic Cancer Trial of CSF-1R Inhibitor -Pimicotinib (ABSK021)in China 28 November 2023, Shanghai – Abbisko Therapeutics Co., Ltd. (“Abbisko Therapeutics” hereafter) today announced the first patient has been do...
医博士编译: Milinkeviciute G, Chokr SM & Cramer K. Auditory Brainstem Deficits from Early Treatment with a CSF1R Inhibitor Largely Recover with Microglial Repopulation. Cureus. 2021; 8(2):ENEURO.0318-20.2021. 原文链接:https://pubmed.ncbi.nlm.nih.gov/33558268/ ...
We depleted macrophages and microglia using GW2580, a small colony stimulating factor-1 receptor (CSF-1R) kinase inhibitor, in MRL-lpr/lpr (MRL/lpr) mice, a classic murine lupus model that displays features of both LN and NPSLE. Treatment was initiated before the onset of disease, and mice...
顺便提一下,文章称他们的分子为switch-control kinase inhibitor,他们之前有一个上市的KIT抑制剂Ripretinib (DCC-2618),也称为switch-control kinase inhibitor,但感觉就是type Ⅱ inhibitor,也许他们的能更有效地将kinase锁定在inactive状态 (文中提到一两处,...
CSF-1R Inhibitor Development: Current Clinical Status 来自 Springer 喜欢 0 阅读量: 108 作者:F Peyraud,S Cousin,A Italiano 摘要: PURPOSE OF REVIEW: Colony-stimulating factor 1 receptor (CSF-1R) and its ligands, CSF-1 and interleukin 34 (IL-34), regulate the function and survival of tumor-...