总之,这些发现表明,BLZ945在降低急性SIV感染期间恒河猴大脑中的病毒负荷方面是安全且有效的。 信息来源:CSF1R inhibition depletes brain macrophages and reduces brain virus burden in SIV-infected macaques Brain, awae153, https://doi.org/10.1093/brain/awae153 Published: 25 July 2024 编译:松鼠哥...
总之,这些发现表明,BLZ945在降低急性SIV感染期间恒河猴大脑中的病毒负荷方面是安全且有效的。 信息来源:CSF1R inhibition depletes brain macrophages and reduces brain virus burden in SIV-infected macaques Brain, awae153, doi.org/10.1093/brain/a Published: 25 July 2024 编译:松鼠哥 发布于 2024-08-05 13...
相关研究结果发表在2020年7月15日的Science Translational Medicine期刊上,论文标题为“Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance”。论文通讯作者为路德维希癌症研究所的Johanna Joyce博士和Leila Akkari博士。 图片来自Science Transla...
CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013;19:1264-72.Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 2013;19:1264-72....
CSF-1-activated macrophages induce inflammatory response and tissue damage, accelerate abnormal tissue repair and fibrosis, and lead to cGVHD. Recent studies have shown that inhibition of CSF1-R can reduce the expansion and infiltration of donor-derived myeloid macrophages in recipient tissues, w...
Microglial abnormality and heterogeneity are observed in autism spectrum disorder (ASD) patients and animal models of ASD. Microglial depletion by colony stimulating factor 1-receptor (CSF1R) inhibition has been proved to improve autism-like behaviors in
In this study, we demonstrate that CSF-1R inhibition inhibits the viability of BMDMs, blocks LAMs polarization and reduces the abundance of LAMs in T-ALL mice. In vivo, combination treatment of CSF-1R inhibitor and vincristine (VCR) dramatically increased the survival of T-ALL mice and delayed...
Inhibition of CSF-1R was investigated in the murine bone marrow derived macrophages (BMDMs) for cell-based assay. Furthermore, the immunocompetent Balb/c mice were subcutaneously implanted 4T1 breast cancer cells in the right flank. Mice were randomized into groups of 9 and treated with C019199...
[3] Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic ...
斯特拉坎DC(Strachan DC),鲁菲尔B(Ruffell B),奥伊Y(Oei Y),比塞尔MJ (Bissell MJ),库森斯LM(Coussens LM),普莱尔N(Pryer N),丹尼尔D(Daniel D).CSF1R抑 制通过减弱肿瘤相关巨噬细胞的更新和增强CD8 T细胞的浸润来延迟鼠类模型中的宫颈和 乳腺肿瘤生长(CSF1R inhibition delays cervical and mammary tumor ...