Many conditions may cause increases in CSF total protein: infections, such as acute or chronic meningitis; multiple sclerosis (when oligoclonal protein bands are present); Guillain-Barré syndrome; and chronic medical conditions like cirrhosis and hypothyroidism (when diffuse hypergammaglobulinemia is pr...
CSF T-cell subsets in multiple sclerosis: relationship to cerebrospinal fluid myelin basic protein and clinical activity. J. Neurol. 236, 336-339.CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity[J] . A. Salmaggi,L. Mantia,...
–Cerebrospinal fluid (CSF) from 221 patients with multiple sclerosis (MS) and 85 patients with other neurological disorders (OND) was examined using a competitive radioimmunoassay for myelin basic protein (MBP) immunoreactivity. MBP was found in 46 of 55 MS patients (84%) examined within six we...
PROTEIN. Total protein levels in CSF are normally very low, and albumin makes up approximately twothirds of the total. High levels are seen in many conditions including bacterial and fungal meningitis, multiple sclerosis, tumors, subarachnoid hemorrhage, and traumatic tap. LACTATE. The CSF lactate...
Results from studies have revealed that autoimmune mechanisms have been implicated in the etiology of HaNDL through protein microarray screening. Findings include the identification of antibodies to 3 DNA repair proteins (mitogen-activated protein kinase-4, DNA-dependent protein kinase catalytic subun...
CSF protein electrophoresis—separates different types of protein; oligoclonal bands are often seen with multiple sclerosis and sometimes with other conditions. CSF IgG (Immunoglobulin G)—increased in some conditions, such as multiple sclerosis, herpes encephalitis, connective tissue diseases Myelin basic...
a, Fgf17 is predominantly expressed in the brain based on the human protein atlas. b, Fgf17 is expressed by cortical glutamatergic neurons in the young adult mouse (Allen brain atlas). c, Sub-clustering of mouse cortical layer 4/5 neurons indicates expression by a subset of cortical neurons...
This activity is measured against a methylumbelliferone standard curve, and the activity is expressed in nmol/h/mL (plasma, CSF) and in nmol/h/mg protein (specific activity for the other samples). Metachromatic leukodystrophy (MLD) patients were used as controls due to sample availability. ...
Macrophage inflammatory protein-3 MS: Multiple sclerosis NIND: Non-inflammatory neurological diseases OCBs: Oligoclonal bands OIND: Other inflammatory neurological diseases SDF-1: Stromal cell-derived factor-1 TACI: Transmembrane activator and CAML interacting protein TNF: Tumor necrosis factor ...
(hASA) into the hippocampus leads to widely distributed expression of hASA protein and a subsequent reduction in sulfatide levels throughout the brain6. To apply this approach to large animals, including humans, multiple vector injections with invasive surgical trepanation of the skull is required ...