基于 SILAC 的定量蛋白质组学可以用于鉴定外源性蛋白质-蛋白质相互作用 (Protein–protein interactions, ...
Using the sodium sulfate precipitation radioimmunoassay and solid-phase radioimmunoassay, we measured antibody to intact human myelin basic protein and myelin basic protein peptic fragments, residues 1-44, 45-89, and 90-170, in CSF. Comparable levels of binding were obtained for MS and normal CSF...
In total, 2615 proteins were identified in the CSF. The number of proteins identified per individual sample ranged from 1109 to 1421, with inter-individual variability between six samples of 21聽%. Based on the Human Protein Atlas, 78 brain-specific proteins found in CSF samples were proposed ...
Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis (vol 16, pg 601... CSF) of patients with ALS that can predict prognosis.DESIGN, PARTICIPANTS, AND SETTING We conducted a retrospective study of plasma (n =...
Objective: We were aiming to investigate the relationship of novel CSF biomarkers NFL, CXCL 13 with established CFS parameters, such as IgG ratio, presence of OCB, number of monocytes and Albumin-ratio (Alb-ratio) in CSF. Background: Neurofilament light (NFL)-biomarker of axonal damage is a...
该文章采用LiP-MS对衰老过程中脑脊液(CSF)蛋白质的丰度和结构变化进行了系统研究。研究发现,38个蛋白质组在衰老过程中丰度发生变化,尤其是IgM亚类的免疫球蛋白显著增加。此外,研究还鉴定出6个高置信度的蛋白质在衰老过程中发生结构变化,其中一些与阿尔茨海默病(AD)密切相关。通过Western blot验证,Cd5l与IgM形成共价...
Volumes of 2L CSF were undertaken a simple, fast extraction procedure involving protein precipitation with methanol and dilution. Ceramides were separated by nano-liquid chromatography with a reversed phase C8 column and detected with a triple quadrupole mass spectrometer. C17:0 ceramide was used as ...
该文章采用LiP-MS对衰老过程中脑脊液(CSF)蛋白质的丰度和结构变化进行了系统研究。研究发现,38个蛋白质组在衰老过程中丰度发生变化,尤其是IgM亚类的免疫球蛋白显著增加。此外,研究还鉴定出6个高置信度的蛋白质在衰老过程中发生结构变化,其中一些与阿尔茨海默病(AD)密切相关。通过Western blot验证,Cd5l与IgM形成共价...
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Cerebrospinal fluid (CSF) of clinically definite Japanese MS patients were studied in Japan as well as in two laboratories in Europe and U.S.A. We confirmed previous findings of 1) lower incidence of elevated IgG and IgG/total protein ratio, 2) lower incidence of oligoclonal IgG bands, and...