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Learn how an integrated structural biology workflow can be used to get crucial structural insights on key protein targets that are of therapeutic interest. 0:00 Ask the Experts: Routine sub-2.5 Å cryo-EM structure determination of GPCRs for drug design Topic: Routine sub-2.5 Å cryo-...
Numerous advancements in cryo-EM have increased the efficiency, ease-of-use and throughput of the workflow, allowing this technique to become an invaluable tool for the pharmaceutical industry. Download the Cryo-EM Trends for Drug Discovery eBook to learn more about the applications and supporting ...
Latest release: CryoSPARC v4.6.2 November 18, 2024 Solutions Extract valuable insight from single particle cryo-EM data CryoSPARC combines powerful innovations in 3D reconstruction algorithms with specially designed software to provide a streamlined end-to-end single particle cryo-EM workflow. Rapidly so...
A standard cryo-EM workflow involves an iterative process of freezing many grids of varying quality and then screening for successful specimens using a cryogenic electron microscope. This process requires the manual handling of small, fragile grids under cryogenic conditions. The quality of resulting ...
Latest release: CryoSPARC v4.6.2 November 18, 2024 Solutions Extract valuable insight from single particle cryo-EM data CryoSPARC combines powerful innovations in 3D reconstruction algorithms with specially designed software to provide a streamlined end-to-end single particle cryo-EM workflow. Rapidly so...
“cryo-EM”) services to the pharmaceutical and biotechnology communities, andCube Biotech, a pioneer in membrane protein production and purification technologies, have announced a partnership agreement to develop a streamlined, cryo-EM enabled gene-to-structure workflow, to ultimately accelerate medicinal...
Workflow for single-particle cryo-EM Step 1: Purify To study molecules by single-particle cryo-EM, a specimen must be purified and structurally intact to produce high-quality 3D reconstructions. Ideally, you need to maintain the specimen in a buffer solution that keeps it biochemically active. ...
“cryo-EM”) services to the pharmaceutical and biotechnology communities, and Cube Biotech, a pioneer in membrane protein production and purification technologies, have announced a partnership agreement to develop a streamlined, cryo-EM enabled gene-to-structure workflow, to ultimately accelerate ...
6 - SPA Reconstruction Basic Workflow - G. Jensen㊶ 31:53 Part6- SPA Reconstruction Additional Topics - G. Jensen㊷ 44:28 Part6- SPA Interpretations and Limitations - G. Jensen㊸ 38:48 Part7- 2D Crystallography Intro and Sample Prep - G. Jensen㊹ 06:25 Part7- FT ...