et al. NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 126, 205–218 (2006). This paper demonstrates the connection between pH regulation, antigen degradation and cross-presentation. Article CAS PubMed Google Scholar Jancic, C. et al....
Dendritic cells (DC) have a critical role in HIV infection as they are the only antigen-presenting cells able to activate naive T cells and elicit the strong specific T-cell responses crucial to control HIV replication. The antigen presentation pathways used by DCs to generate these responses ...
USAAbstractAntigencross-presentationdescribestheprocessthroughwhichdendriticcells(DCs)acquireexogenousantigensforpresentationonMHCclassImolecules.Theabilitytocross-presenthasbeenthoughtofasafeatureofspecializedDCsubsets.Emergingdata,however,suggestthatthecross-presentingabilityofeachDCsubsetistunedbyanddependentonseveral...
Cross-presentation of IgG-containing immune complexes (ICs) is an important means by which dendritic cells (DCs) activate CD8 T cells, yet it proceeds by a... K Baker,SW Qiao,TT Kuo,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 207...
Priming CD8+ T cells against these viruses is thought to rely solely on cross-presentation by uninfected TAP-functional dendritic cells. We found that protective CD8+ T cells could be mobilized during viral infection even when TAP was absent in all hematopoietic cells. TAP blockade depleted the ...
Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presentin...
Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-cell adaptive responses. Cancer cells express tumor antigens, including neoantigens generated by nonsynonymous mutations, but are poor for antigen presentation and for providing costimulatory signals for T-cell ...
by NOX2 (NSDPH oxidase). In the absence of NOX2, the dendritic phagosomal lumen is acidified, degradation is increased, and cross-presentation is impaired (Savina A et al 2006 Cell 126:205). The result of cross-presentation may be either cross-priming of the cytotoxic T cells or T cell...
Cross-presentation by dendritic cells The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8(+) T cell responses. I... OP Joffre,E Segura,A Savina,... - 《Nature Reviews Immunology》 被引量: 1006发表: 2012年 ...
Dead-cell-associated proteins are an important source of antigens for cross-presentation by dendritic cellsWe recently had the opportunity to read the Opinion article by Matthew Albert1 that was published in Nature Reviews Immunology. Because this article is probably of interest to many scientists, ...