Limited proteolysis in the endocytic compartments of dendritic cells (DCs) favours cross-presentation by preventing the destruction of internalized antigens. In the cytosolic pathway, exogenous antigens are translocated from endosomal compartments into the cytosol for degradation by the proteasome. The mole...
Antigen PresentationCross-PrimingMice, TransgenicDendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts, ...
Allan, R. S. et al. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming.Immunity25, 153–162 (2006). ArticleCASPubMedGoogle Scholar Backer, R. et al. Effective collaboration between marginal metallophilic macrophages and CD8+dendri...
Cross-presentation of IgG-containing immune complexes (ICs) is an important means by which dendritic cells (DCs) activate CD8 T cells, yet it proceeds by a... K Baker,SW Qiao,TT Kuo,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 207...
Cross-presentation by dendritic cells The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8(+) T cell responses. I... OP Joffre,E Segura,A Savina,... - 《Nature Reviews Immunology》 被引量: 1006发表: 2012年 ...
USAAbstractAntigencross-presentationdescribestheprocessthroughwhichdendriticcells(DCs)acquireexogenousantigensforpresentationonMHCclassImolecules.Theabilitytocross-presenthasbeenthoughtofasafeatureofspecializedDCsubsets.Emergingdata,however,suggestthatthecross-presentingabilityofeachDCsubsetistunedbyanddependentonseveral...
Dendritic cells (DCs) were identified as the subset of myeloid cells most efficient at cross-presentation [3]. Discoveries over recent years suggest that a very specific subset of DCs excels at cross-presentation [4, 5], and equivalent subsets have been characterized in humans [6., 7., 8...
The term cross-presentation denotes the presentation of exogenous (extracellular) antigens to T cells, particularly CD8 T cells. It permits professional an
Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presentin...
B Lymphocytes Participate in Cross-Presentation of Antigen following Gene Gun Vaccination Whereas the ability of dendritic cells (DCs) to cross-present Ags is well documented, it is not known whether other APCs may also play a role, or ......