In the journal "Science Express," researchers have shown that female mice are protected from hardening of arteries as a result of oestrogen activation of the cyclooxygenase-2 enzyme, which causes an increase in the amount of the atheroprotective molecule prostacyclin. During inflammation, phospholipase...
Additionally, we evaluated the NF-魏B/COX-2 pathway and iNOS levels. The active constituents detected inwere demethoxycurcumin and bisdemethoxycurcumin, and that detected inwas methylsulfonylmethane. Anassessment determined the appropriate drug ratio as 3:7. In a carrageenan-induced inflammatory ...
通过影响HIF一1/c0x_2信号通路发挥其抗癌作用. 关键词:肝癌;低氧诱导因子一1n;环氧合酶一2;柴胡皂甙d 中图分类号:R735.7文献标志码:A文章编号:1671-8259(2011)01—0080—05 TheroleofsaikosaponindinregulatingHIF-la/COX一2signal transductionpathwayinhumanhepat0ce儿ularcarcinomacells HOUHe—lei,HEShui—xiang...
IL-1β减轻脂肪细胞的褐变,但通过在IL-1β中添加Apg可以增强脂肪褐变。 用Apg处理的脂肪细胞显示出较低的炎症标记基因表达以及较高的COX2和PGE2表达水平。阻断PGE2生物合成的限速酶(COX2)或抑制PGE2受体(EP4)会干扰Apg介导的UCP1诱...
Cianchi F, Perna F and Masini E (2005): `'INOS/COX-2 pathway interaction: a good molecular target for cancer treatment'' Current Enzyme Inhibition., 97-105.Cianchi F, Perna F, Masini E. iNOS/COX-2 pathway interaction: a good molecular target for cancer treatment . Current Enzyme...
pathway: key roles in the hallm arks of cancer and adaptation to the tum our m icroenvironm ent. Carcinogenesis,2009,30(3):377-386. [8] 吴卓娜,窦梅芝,孟志云.CO X -2选择性抑制剂及其心 血管安全性研究进展[J].解放军药学学 报.2009,25(2):62—64. [9] 张长青.CO X -2抑制剂与心...
Characterization of pro- staglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils. Biochim Biophys Acta 2007; 1771: 1235-45.St-Onge M, Flamand N, Biarc J, Picard S, Bouchard L, Dussault A-A, Laflamme C, James MJ, Caughey GE, Cleland LG, Borgeat P, ...
The aims of the present work were: a) to describe, the number and the distribution of TAMs in canine melanocytic lesions; b) to investigate associations between TAMs and several clinicopathological characteristics; c) investigate...
2023年7月21日,南开大学药学院李成刚、重庆大学中心医院狄邵等教授的研究团队在国际知名期刊Clinical and Translational Medicine(IF=10.6)上发表了题为Glutaredoxin-1 promotes lymphangioleiomyomatosis progression through inhibiting Bim-med...
产品货号 产品规格 目录价 54114ES76 500 mg 325.00 54114ES92 10 g 435.00 批量采购,请点击询价 产品说明书 FAQ COA 已发表文献 产品性质 英文别名(English Synonym) Salicylicacid 中文名称(Chinese Name) 水杨酸 靶点(Target) COX 通路(Pathway)