COX2是一个酶,能够催化花生四烯酸(AA)转化为PGE2。PGE2是一种前列腺素,能够通过激活ERK通路促进细胞生长和存活。 在LAM研究中,研究团队观察到TSC2缺陷细胞中Glrx表达异常,TSC2以非依赖mTORC1的方式负性调节Glrx-1的过度激活。异常的...
APG在有炎症信号的情况下有助于缓解脂肪细胞褐变,这种作用至少部分是通过减轻炎症和诱导PGE2/EP4信号轴介导实现的。 研究结论 Apg通过减少炎症反应、促进COX2和PGE2的生成以及将PGE2信号转导至EP4刺激和cAMP激活来调节其作用。Apg对COX2...
In the following research, whether Helicobacter pylori induced vascular endothelial growth factor (VEGF) expression in human gastric cancer cells through COX-2-PGE2 pathway was analyzed.Ming ZhouJian TanMing HuTan WangQ. HuJournal of Hainan Medical University...
方法 Real-Time PCR 和 Western blot 检测 SW1116 细胞、SW1116/HCPT 细胞,以及下调 PPARα 表达后 SW1116 细胞中 COX-2 的表达差异;ELISA 检测 WY-14643分别干预 SW1116 细胞,SW1116/HCPT 细胞,以及下调 PPARα 表达后各组细胞培养上清中 PGE2含量;流式细胞术检测不同浓度 PGE2 对细胞周期的影响。结果 ...
increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, COX2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. COX2 is naturally inhibited ...
PI3-kinase/Wnt association mediates COX-2/PGE2 pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. Tumor Biol. 31, 623–631 (2010). https://doi.org/10.1007/s13277-010-0078-9 Download citation Received21 May 2010 Accepted29 June 2010 Published09 ...
Greenhough A, Smartt HJ, Moore AE, Roberts HR, Williams AC, Paraskeva C, Kaidi A: The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis. 2009, 30 (3): 377-386. 10.1093/carcin/bgp014. Article CAS PubMed Google Schola...
Interestingly, overall increase in PGE2 levels in treated 293T cells was not so robust (from 214 pg/ml to 275 pg/ml) (p<0.01). This is most likely due to the low expression levels of TLR4 receptors on 293T cells which are critical for LPS signaling pathway (Medvedev and Vogel, 2003)...
increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, COX2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. COX2 is naturally inhibited ...
PPARα_COX-2_PGE2通路在人结肠癌耐药细胞中的作用研究 万方数据